Skip to main content
Log in

Aminomethylation of substituted 5-hydroxypyrimidines

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Conditions that make it possible to obtain aminomethyl derivatives of 2-R-4,6-dimethyl-5-hydroxypyrimidine that are substituted both in the pyrimidine ring (R = H) and at the methyl group of the side chain (R = H, CH3, C6H3) were found. The facts established in this research make it possible to propose various substitution mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literature cited

  1. S. B. Gashev and L. D. Smirnov, Izv. Akad. Nauk SSSR, Ser. Khim.,22, 678 (1979).

    Google Scholar 

  2. N. V. Khromov-Borisov and R. S. Karlinskaya, in: Memories of A. E. Porai-Koshits [in Russian], Goskhimizdat, Leningrad (1949), p. 121.

    Google Scholar 

  3. K. M. Dyumaev, L. D. Smirnov, and B. F. Bystrov, Izv. Akad. Nauk SSSR, Ser. Khim.,5, 883 (1962).

    Google Scholar 

  4. L. D. Smirnov, V. P. Lezina, T. P. Kartasheva, and K. M. Dyumaev, Izv. Akad. Nauk SSSR, Ser. Khim.,11, 199 (1968).

    Google Scholar 

  5. H. Hellmann and G. Opitz, α-Aminoalkylierung, Verlag Chemie, Weinheim (1960).

    Google Scholar 

  6. T. F. Gummings and J. R. Shelton, J. Org. Chem.,25, 419 (1960).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 681–683, May, 1980.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gashev, S.B., Lezina, V.P. & Smirnov, L.D. Aminomethylation of substituted 5-hydroxypyrimidines. Chem Heterocycl Compd 16, 532–534 (1980). https://doi.org/10.1007/BF00561355

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00561355

Keywords

Navigation