Venoconstrictor effect of dihydroergotamine in superficial hand veins
- 27 Downloads
The effect of dihydroergotamine on superficial veins of the hand has been investigated in healthy volunteers. The compliance of the veins was assessed by measurement of their diameter at a standard congestion pressure. Direct local infusion into the vein under study of 0.4 µg and 2.0 µg dihydroergotamine reduced venous compliance by 15±5% and 30±3%, respectively. Local infusion of phentolamine 20 µg, an α-adrenoceptor blocking drug, did not affect venous compliance, but markedly inhibited the venoconstrictor effect of dihydroergotamine 2 µg. It was concluded that the venoconstrictor effect of dihydroergotamine demonstrated in this experiment was mainly due to α-adrenoceptor stimulation. Venous compliance also decreased after oral administration of dihydroergotamine 10 mg; after 150 min, venous diameter was reduced by 30±5%.
Key wordsDihydroergotamine phentolamine venoconstriction venous compliance α-adrenoceptor blockade
Unable to display preview. Download preview PDF.
- Aellig, W.H.: Studies on the venoconstrictive effect of dihydroergotamine in man. Arch. Pharmacol.279, Suppl. R 43 (1973)Google Scholar
- Goodman, L.S., Gilman, A.: The pharmacological basis of therapeutics, 4th Ed., pp 557–559. New York: Macmillan 1970Google Scholar
- Mellander, S., Nordenfelt, I.: Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance functions in the peripheral circulation. Clin. Sci.39, 183 (1970)Google Scholar
- Müller-Schweinitzer, E.: Investigations on the mode of action of dihydroergotamine in human saphenous and dog saphenous and femoral veins. Arch. Pharmacol. 279, Suppl. R 44 (1973)Google Scholar
- Nachev, C., Collier, J., Robinson, B.: Simplified method for measuring compliance of superficial veins. Cardiovasc. Res.5, 147 (1971)Google Scholar
- Rieckert, H., Pauschinger, P.: Die Beeinflussung des peripheren Venentonus durch Dihydergot. Ärztl. Forsch.3, 99 (1967)Google Scholar