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European Journal of Clinical Pharmacology

, Volume 7, Issue 2, pp 137–139 | Cite as

Venoconstrictor effect of dihydroergotamine in superficial hand veins

  • W. H. Aellig
Originals

Summary

The effect of dihydroergotamine on superficial veins of the hand has been investigated in healthy volunteers. The compliance of the veins was assessed by measurement of their diameter at a standard congestion pressure. Direct local infusion into the vein under study of 0.4 µg and 2.0 µg dihydroergotamine reduced venous compliance by 15±5% and 30±3%, respectively. Local infusion of phentolamine 20 µg, an α-adrenoceptor blocking drug, did not affect venous compliance, but markedly inhibited the venoconstrictor effect of dihydroergotamine 2 µg. It was concluded that the venoconstrictor effect of dihydroergotamine demonstrated in this experiment was mainly due to α-adrenoceptor stimulation. Venous compliance also decreased after oral administration of dihydroergotamine 10 mg; after 150 min, venous diameter was reduced by 30±5%.

Key words

Dihydroergotamine phentolamine venoconstriction venous compliance α-adrenoceptor blockade 

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References

  1. Aellig, W.H.: Studies on the venoconstrictive effect of dihydroergotamine in man. Arch. Pharmacol.279, Suppl. R 43 (1973)Google Scholar
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  4. Müller-Schweinitzer, E.: Investigations on the mode of action of dihydroergotamine in human saphenous and dog saphenous and femoral veins. Arch. Pharmacol. 279, Suppl. R 44 (1973)Google Scholar
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • W. H. Aellig
    • 1
  1. 1.Experimental Therapeutics Department, Biological and Medical Research DivisionSandoz Ltd.BasleSwitzerland

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