European Journal of Clinical Pharmacology

, Volume 4, Issue 3, pp 158–161 | Cite as

Plasma concentrations of cardiac glycosides in digitalis intoxication

  • G. Somogyi
  • A. Káldor
  • A. Jankovics
Originals

Summary

Using the method of Löwenstein and Corrill modified by the authors the relationship between measured plasma digitalis concentrations and symptoms and signs of toxicity was studied in cases of suicide and accidental poisoning. Direct relationship could not be detected between plasma levels and clinical symptoms. Severe toxic symptoms occured only in the presence of high levels. Nevertheless, patients with high plasma levels may be symptom-free. Parallelism was observed between a fall in the digitalis level and the disappearance of clinical symptoms.

Key words

Digitalis intoxication digoxin assay suicide forensic 

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References

  1. 1.
    Okita, G.T., Kelsey, F.E., Walaszek, E.J., Geiling, E.M.K.: Biosynthesis and isolation of carbon-14 labelled digitoxin. J. Pharmacol. exp. Ther.110, 244 (1954).Google Scholar
  2. 2.
    —— Metabolism of radioactive cardiac glycosides. Pharmacologist6, 45 (1964).Google Scholar
  3. 3.
    Doherty, J.E.: The clinical pharmacology of digitalis glycosides: A Review. Amer. J. med. Sci.255, 382 (1968).Google Scholar
  4. 4.
    Lowenstein, J.M., Corill, E.M.: An improved method for measuring plasma and tissue levels of digitalis glycosides. J. Lab. clin. Med.67, 1048 (1966).Google Scholar
  5. 5.
    Butler, V.P., jr., Chen, J.P.: Digoxin-specific antibodies. Proc. nat. Acad. Sci.57, 71 (1967).Google Scholar
  6. 6.
    Somogyi, G., Kàldor, A.: Plasma concentration of G-strophantoside. Orv. Hetil.36, 2088 (1969).Google Scholar
  7. 7.
    Lukas, D. S., Peterson, R.E.: Double isotope dilution derivate assay of digitoxin in plasma, urine and stool of patients maintained on the drug. J. clin. Invest.45, 782 (1966).Google Scholar
  8. 8.
    Weissler, A.M., Snyder, J.R., Schonnfeld, C.D., Cohen, S.: Assay of digitalis glycosides in man. Amer. J. Cardiol.17, 768 (1966).Google Scholar
  9. 9.
    Bentley, J.D., Burnett, G.H., Conklin, R.L., Wasserburger, R.H.: Clinical application of serum digitoxin levels. Circulation16, 67 (1970).Google Scholar
  10. 10.
    Arreguine, V.: Rev. univ. nac. Cordoba (Argentinien) Cit: Die herzwirksamen Glykoside, p. 165. Leipzig: VEB Georg Thieme 1963.Google Scholar
  11. 11.
    Surawicz, B., Mortelmans, S.: Digitalis, p. 127, New York: Grune and Stratton 1969.Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • G. Somogyi
    • 1
    • 2
  • A. Káldor
    • 1
    • 2
  • A. Jankovics
    • 1
    • 2
  1. 1.2nd Medical Department of the Semmelweis University Medical SchoolBudapestHungary
  2. 2.the Traumatologic Medical Department of the Korányi Frigyes and Korányi Sándor HospitalBudapestHungary

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