European Journal of Clinical Pharmacology

, Volume 36, Issue 1, pp 91–92 | Cite as

5-Methoxypsoralen increases evening sleepiness in humans: Possible involvement of the melatonin secretion

  • E. Souêtre
  • E. Salvati
  • J. -L. Belugou
  • B. Krebs
  • G. Darcourt
Short Communications

Summary

The acute and short-term effect of 5-methoxypsoralen (5-MOP) on daytime sleepiness was investigated in 12 healthy subjects according to a double-blind cross-over design. 5-MOP (40 mg/day) or placebo was orally administered (one week each) at 16.00 h. 5-MOP significantly increases daytime sleppiness 4 to 5 h after administration without affecting the subsequent sleep efficiency and duration. We found a positive correlation between sleepiness and melatonin levels.

Our findings suggest that the melatonin secretion may play a role in the effect of 5-MOP on sleepiness in humans.

Key words

psoralen melatonin sleepiness 

References

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • E. Souêtre
    • 1
    • 2
  • E. Salvati
    • 1
  • J. -L. Belugou
    • 1
  • B. Krebs
    • 3
  • G. Darcourt
    • 1
  1. 1.Clinique de psychiatrie et de psychologie médicale, serv. Pr. G. DarcourtHôpital PasteurNiceFrance
  2. 2.Clinical Psychobiology BranchNational Institute of Mental HealthBethesdaUSA
  3. 3.Laboratoire de radioimmunologie, Dr. B. Krebs Centre Antoine LacassagneNiceFrance

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