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European Journal of Clinical Pharmacology

, Volume 36, Issue 1, pp 47–52 | Cite as

The effects of alcohol on psychological funtions in normal volunteers after 8 days' treatment with pipequaline (PK 8165), diazepam or placebo

  • F. F. Eves
  • M. H. Lader
Article

Summary

The effects of daily administration for 8 days of 50 mg pipequaline, 10 mg diazepam and placebo were assessed in a double-blind cross-over study with 12 healthy volunteers. This study also tested for an interaction between the drugs and alcohol on the eighth day. Subjective ratings, psychomotor and memory performance were evaluated.

Diazepam produced the typical pattern of changes, namely impairments in psychomotor performance and reductions in the retention of newly memorised information.

In contrast, the effects of pipequaline were relatively minor. In general, neither drug potentiated the effects of alcohol on performance, only isolated instances of non-additive interactions occurring. Subjective reports revealed that whereas both active drugs increased feelings of calmness, this result was accomplished by pipequaline with considerably less drowsiness, no euphoria and a general absence of the adverse side effects of diazepam.

Key words

pipequaline (PK 8165) diazepam alcohol psychomotor performance adverse effects healthy volunteers 

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References

  1. Baddeley AD (1976) The psychology of memory. Basic Books, New YorkGoogle Scholar
  2. Benavides J, Malgouris C, Flamier A, Tur C, Quarteronet D, Begassat F, Cameli J-C, Uzan A, Gueremy C, Le Fur G (1984) Biochemical evidence that 2-phenyl-4(2-(4-piperidinyl)ethyl) quinoline, a quinoline derivative with pure anticonflict properties, is a partial agonist of benzodiazepine receptors. Neuropharmacology 23: 1129–1136Google Scholar
  3. Bond AJ, Lader MH (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47: 211–218Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • F. F. Eves
    • 1
  • M. H. Lader
    • 1
  1. 1.Department of PsychiatryInstitute of PsychiatryLondonUK

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