European Journal of Clinical Pharmacology

, Volume 5, Issue 1, pp 22–27 | Cite as

The measurement of plasma digoxin concentration: A comparison of two methods

  • S. Lader
  • A. Bye
  • P. Marsden
Originals

Summary

No significant differences were found between plasma digoxin concentrations in samples assayed by both radioimmunoassay and86Rb uptake. The mean plasma digoxin concentration in 27 patients on a stable maintenance dose of digoxin was 1.1±0.6 ng/ml, while that in a group of 12 patients with clinical evidence of full or overdigitalization was 2.2±0.6 ng/ml, which was significantly greater (p<0.05).

Key words

Plasma digoxin concentration radioimmunoassay 86Rb uptake method 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • S. Lader
    • 1
    • 2
  • A. Bye
    • 1
    • 2
  • P. Marsden
    • 1
    • 2
  1. 1.Department of Clinical PharmacologyWellcome Foundation LimitedBeckenhamEngland
  2. 2.the Department of MedicineKing's College Hospital Medical SchoolLondonEngland

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