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Increase of melanocytes around malignant melanoma

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Summary

In split epidermal sheets with clinically normal appearance a quantitative study was carried out on dopa-positive cells in the vicinity of malignant melanomas. These data were then compared with the number of melanocytes found in the skin of the contralateral body side of the same patient. In the epidermis around superficial spreading melanoma and lentigo maligna melanoma, the number of dopa-positive cells was usually significantly higher than in the contralateral body side. On the other hand, no difference was generally found around nodular melanoma.

Zusammenfassung

An Epidermis-Totalpräparaten klinisch normaler Haut aus der Umgebung maligner Melanome wurde die Zahl der Melanocyten bestimmt und mit den Melanocytenwerten verglichen, die für die Epidermis der kontralateralen Körperseite des gleichen Patienten ermittelt werden konnten. In der Umgebung oberflächlich spreitender Melanome und Dubreuilh-Melanome waren die Melanocyten — verglichen mit den Werten der kontralateralen Körperseite — meist signifikant erhöht. Keine Unterschiede bestanden dagegen im allgemeinen beinodulären Melanomen.

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Authors and Affiliations

  1. Melanom-Forschungs-Laboratorium, Abteilung für klinische und experimentelle Dermatologie, Gießen, FRG

    E. Paul

  2. Zentrum für Dermatologie, Andrologie und Venerologie, Justus Liebig-Universität, Gießen, FRG

    E. Gernand

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  1. E. Paul
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  2. E. Gernand
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Paul, E., Gernand, E. Increase of melanocytes around malignant melanoma. Arch. Derm. Res. 252, 275–283 (1975). https://doi.org/10.1007/BF00560367

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