European Journal of Clinical Pharmacology

, Volume 7, Issue 6, pp 467–471 | Cite as

Disappearance of phenazone from plasma in patients with obstructive jaundice

  • J. Elfström
  • S. Lindgren


The influence of obstructive jaundice on the plasma disappearance of phenazone has been studied. The elimination rate of the drug reflects the ability of the liver to hydroxylate it and possibly other drugs, too. A new analytical method based on gas chromatography was used for the determination of phenazone in plasma. The study was performed in 11 patients with jaundice due to stones in the common bile duct, both during the icteric period and three months later, when the obstruction had been relieved and the plasma bilirubin had returned to normal. A separate group, consisting of five patients with jaundice due to malignant disease, was studied only once. The study failed to show a uniform influence of obstructive jaundice on the elimination rate of phenazone. In two other non-icteric patients the excretion of phenazone in bile was found to be less than 2% of the dose administered.

Key words

Phenazone obstructive jaundice plasma elimination drug metabolism biliary excretion 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. Elfström
    • 1
  • S. Lindgren
    • 1
  1. 1.Surgical Clinic and Department of Clinical PharmacologyUniversity of LinköpingSweden

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