European Journal of Clinical Pharmacology

, Volume 3, Issue 1, pp 32–35 | Cite as

Comparative drug treatment of endocrine exophthalmos

  • D. A. Koutras
  • A. G. Bouzas
  • D. P. Livadas
  • A. G. Vagenakis
  • A. S. Koukoulommati


The degree of exophthalmos and the width of the palpebral fissure were studied serially in 58 previously thyrotoxic patients, who were divided into 6 treatment groups: 1. guanethidine eye drops; 2. oral thyroxine; 3. guanethidine eye drops and oral thyroxine; 4. guanethidine and prednisolone eye drops; 5. napththazoline nitrate 0.1% and zine sulfate 0.5% eye drops; and 6. metronidazole orally. Exophthalmos increased significantly in the first and third group, and the palpebral fissure decreased in the first group. It was concluded that guanethidine eye drops should be given when there is marked lid retraction with minimal exophtalmos; that prednisolone eye drops are not indicated in endocrine exophthalmos; and that the combination of guanethidine eye drops with oral thyroxine in different dosages is worth further study.


Exophthalmos guanethidine thyroxine prednisolone metronidazole 


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • D. A. Koutras
    • 1
  • A. G. Bouzas
    • 1
  • D. P. Livadas
    • 1
  • A. G. Vagenakis
    • 1
  • A. S. Koukoulommati
    • 1
  1. 1.Department of Clinical Therapeutics, Alexandra HospitalAthens UniversityAthensGreece

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