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European Journal of Clinical Pharmacology

, Volume 14, Issue 1, pp 53–56 | Cite as

Effect of topical application of dexamethasone on propionibacteria in the pilosebaceous duct

  • M. Gloor
  • H. Funder
  • M. Franke
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Summary

A preparation of dexamethasone 0.02% in Eutanol G (n octyldodecanol) was applied once daily for three weeks, to the right side of the forehead of 25 male healthy test subjects. Eutanol G without dexamethasone was applied in the same way to the left side of the forehead. Before and at the end of the treatment period bacteria were removed from the pilo-sebaceous ducts by the method of Holland et al. [8]. Bacteria that grew under anaerobic conditions were evaluated quantitatively. Dexamethasone induced a significant increase in P. acnes, in all Propionibacteria and in the total bacterial count. The importance of these findings is discussed in relation to the development of steroid acne.

Key words

Dexamethasone Eutanol G skin bacteria Propionibacteria steroid acne 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • M. Gloor
    • 1
  • H. Funder
    • 1
  • M. Franke
    • 1
  1. 1.Universitäts-HautklinikHeidelbergFederal Republic of Germany

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