European Journal of Clinical Pharmacology

, Volume 15, Issue 5, pp 319–322 | Cite as

Factors affecting warfarin requirements

A prospective population study
  • P. A. Routledge
  • P. H. Chapman
  • D. M. Davies
  • M. D. Rawlins
Originals

Summary

In 228 ambulatory patients receiving treatment with warfarin, there was a progressive decline in the dose required to produce an equivalent degree of anticoagulant control with increasing age from the third decade onwards. However, the relationship between age and dose was significant only in patients receiving warfarin after episodes of venous thromboembolism or because of coronary artery disease. Patient weight was also related to warfarin requirements, although it was less important a determinant than age.

Key words

warfarin anticoagulation age sex weight 

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References

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • P. A. Routledge
    • 1
    • 2
  • P. H. Chapman
    • 1
    • 2
  • D. M. Davies
    • 1
    • 2
  • M. D. Rawlins
    • 1
    • 2
  1. 1.Department of Pharmacological Sciences, Wolfson Unit of Clinical PharmacologyUniversity of Newcastle upon TyneUK
  2. 2.Department of Clinical PharmacologyShotley Bridge General Hospital, Co.DurhamUK

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