Summary
A GLC method for determination of bendroflumethiazide has been developed, using extractive methylation. Cyclopenthiazide was used as internal standard. The maximal plasma concentration (56–107 ng/ml) after bendroflumethiazide 10 mg given orally to four healthy volunteers was seen at 2–2.5 h. On the slope between 4 and 10 h T1/2 averaged 2.7 h.
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References
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Supported by the Swedish Medical Research Council (Grant No. B 75-04X-227-12 C) and AB Ferrosan, Malmö, Sweden
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Beermann, B., Groschinsky-Grind, M. & Lindström, B. A GLC assay for bendroflumethiazide. Preliminary data about its plasma level in man. Eur J Clin Pharmacol 10, 293–295 (1976). https://doi.org/10.1007/BF00558343
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DOI: https://doi.org/10.1007/BF00558343