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Long term treatment of moderate hypertension with penbutolol (Hoe 893d) III. Effects on glucose tolerance and insulin production

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Summary

Studies in seven patients with moderate hypertension were done to explore the effect of the non-selective beta-receptor blocking agent penbutolol on blood glucose and plasma insulin levels under fasting conditions, and following a glucose load. Oral penbutolol 20–30 mg, twice daily for 3–8 months, produced no change in fasting levels of blood glucose and plasma insulin, or in the blood glucose response following an oral or iv glucose load. The initial insulin response to intravenous glucose was similar before and during penbutolol treatment. The total integrated insulin response following iv glucose increased slightly during treatment when measured from insulin zero level, but was unaltered when calculated from the initial basal insulin level. Following oral glucose the total integrated insulin response was not affected by treatment with penbutolol.

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Authors and Affiliations

  1. Dept. of Internal Medicine and Endocrinology, General Hospital, Malmö, Sweden

    B. -G. Hansson & B. Hökfelt

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  1. B. -G. Hansson
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  2. B. Hökfelt
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Hansson, B.G., Hökfelt, B. Long term treatment of moderate hypertension with penbutolol (Hoe 893d) III. Effects on glucose tolerance and insulin production. Eur J Clin Pharmacol 10, 157–162 (1976). https://doi.org/10.1007/BF00558323

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  • DOI: https://doi.org/10.1007/BF00558323

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