European Journal of Clinical Pharmacology

, Volume 7, Issue 5, pp 343–346 | Cite as

Therapeutic effectivenss and plasma levels of aprindine, a new antidysrhythmic drug

  • J. P. Van Durme
  • M. G. Bogaert
  • M. T. Rosseel


41 patients with stable, frequent, chronic premature ventricular contractions have been treated with aprindine, and its therapeutic effectiveness evaluated by continuous electrocardiographic recording on tape. Excellent results (total suppression of the dysrhythmia) were obtained in 29 patients (71%), in whom the minimal effective plasma level ranged from 0.73 to 2.55 µg/ml (mean 1.35 µg/ml). Neurological side effects developed in 9 patients (22%), with plasma levels from 1.19 to 4.13 µg/ml (mean 2.65 µg/ml). The value of plasma level determinations is discussed.

Key words

Premature ventricular contractions continuous electrocardiography aprindine antidysrhythmics plasma level neurological side effects 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. P. Van Durme
    • 1
  • M. G. Bogaert
    • 1
  • M. T. Rosseel
    • 1
  1. 1.Department of Cardiology and Heymans, Institute of PharmacologyUniversity of Gent, Akademisch ZiekenhuisGentBelgium

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