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In-vitro culture of Kaposi's disease cells

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Summary

Thein-vitro culture of pathological tissue of Kaposi's disease has induced the growth of three cell types: epithelioid cells, apparently not significant, which proliferated from the epithelial component; branched fibroblastoid cells with a large nucleus; and bipolar spindle-shaped cells with a smaller nucleus. The morphological differences constantly present between the fibroblastoid cells and the spindle-shaped ones, as well as their different behaviour when stained with fluorochromes, support the view that these cells are two different entities. Numerical and structural chromosomal modifications were not found in the cultured cells.

Zusammenfassung

Durchin vitro-Züchtung von erkranktem Gewebe wurde beim M. Kaposi das Wachstum von drei Zelltypen beobachtet: epitheloide, sich aus dem epithelialen Anteil entwickelnde Zellen von geringer Bedeutung, verzweigte fibroblastoide Zellen mit großen Kernen, und bipolare spindelige Zellen mit einem kleineren Kern. Die morphologischen Kennzeichen dieser Zelltypen waren konstant zu verzeichnen wie auch ein unterschiedliches Verhalten nach Fluorochrom-Färbung.

Sie berechtigten die Annahme, daß es sich um verschiedenartige Zelltypen handelt.

Numerische oder strukturelle Chromosomenveränderungen fehlten.

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Ottolenghi, F., Andreassi, L., Sbano, E. et al. In-vitro culture of Kaposi's disease cells. Arch. Derm. Forsch. 250, 389–393 (1974). https://doi.org/10.1007/BF00558198

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  • DOI: https://doi.org/10.1007/BF00558198

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