European Journal of Clinical Pharmacology

, Volume 36, Issue 3, pp 319–321 | Cite as

The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers

  • P. A. Philip
  • C. A. James
  • H. J. Rogers
Short Communications


We have studied the effect of cimetidine (800 mg·day−1) administration for three days on debrisoquine 4-hydroxylation in nine healthy extensive metabolizers.

The debrisoquine metabolic ratio was significantly increased (p<0.01), but the new ratios remained in the extensive metabolizer range (<12.6).

These data suggest that pre-treatment with cimetidine in usual therapeutic doses will impair debrisoquine 4-hydroxylation, but not enough to alter the apparent oxidation phenotype.

Key words

cimetidine debrisoquine drug interactions extensive metabolizers 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • P. A. Philip
    • 1
    • 2
  • C. A. James
    • 1
  • H. J. Rogers
    • 1
  1. 1.Department of Clinical PharmacologyUnited Medical and Dental Schools, Guy's HospitalLondonUK
  2. 2.ICRF Clinical Oncology Unit Churchill HospitalHeadingtonUK

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