Skip to main content
SpringerLink
Log in

Dermatosen mit transepithelialer perforation

Dermatoses with Transepithelial Perforation

  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

The histologic concept of epidermal elimination of particulate matter was formulated by Pinkus in 1954. Mehregan enlarged on this by recognizing its fundamental role in a variety of skin diseases. The importance of this epidermal reaction pattern in five “perforating” dermatoses is stressed. Also, it is shown that active participation of the corium and epithelio-mesenchymal interaction are required for the initiation of this mechanism. The histological differentiation and histogenesis of the presented dermatoses are discussed.

Zusammenfassung

Das von H. Pinkus 1954 formulierte biologische Konzept der epidermalen Elimination wurde in der Folge von Mehregan als grundlegendes Prinzip bei einer Reihe von heterogenen Hautkrankheiten erkannt. Die Bedutung dieses epidermalen Reaktionsmusters wird an Hand von fünf “perforierenden” Dermatosen demonstriert und sowohl die aktive Beteiligung des Koriums an diesem Mechanismus, sowie die Rolle epitheliomesenchymaler Wechselbeziehungen hervorgehoben. Es wird die histologische Differentialdiagnose und unterschiedliche Histogenese dieser Krankheitsgruppe diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Bandmann, H. J., Schmid, A. H.: Zur Differentialdiagnose der Hyperkeratosis follicularis und parafollicularis in cutem penetrans (Morbus Kyrle) gegenüber der Elastosis perforans serpiginosa (Morbus Lutz-Miescher). Hautarzt19, 259–264 (1968)

    Google Scholar 

  2. Bardach, H.: Hyperkeratosis follicularis at parafollicularis in cutem penetrans (Morbus Kyrle). Z. Hautkrankh.49, 559–566 (1973)

    Google Scholar 

  3. Bovenmyer, D. A.: Reactive perforating collagenosis.-Experimental production of the lesion. Arch. Derm.102, 313–317 (1970)

    Google Scholar 

  4. O'Brien, J.: Actinic granuloma. Arch. Derm.111, 460–466 (1975)

    Google Scholar 

  5. Carter, V. H., Constantine, V. S.: Kyrles disease.-Clinical findings in five cases and review of the literature. Arch. Derm.97, 624–632 (1968)

    Google Scholar 

  6. Christianson, H. B.: Elastosis perforans serpiginosa: Association with congenital anomalies. South Med. J.59, 15–19 (1966)

    Google Scholar 

  7. Clendenning, W. E., Auerbach, R.: Traumatic calcium deposition in skin. Arch. Derm.89, 360–363 (1964)

    Google Scholar 

  8. Constantine, V. S., Carter, V.H.: Kyrle's disease.-Histopathologic findings in five cases and review of the literature. Arch. Derm.97, 633–639 (1968)

    Google Scholar 

  9. Duperrat, B., Vanbremeersch, F.: Ostéome perforant verruciforme post-traumatique. Ann. Derm. Syph.90, 37–39 (1963)

    Google Scholar 

  10. Freudenthal, W.: Amyloid in der Haut. Arch. Derm. Syph.162, 40–94 (1930)

    Google Scholar 

  11. De Graciansky, P., Boulle, S., Boulle, M., Dalion, J.: La maladie de Kyrle: Etude critique a propos d'une observation. Ann. Derm. Syph.82, 8–33 (1955)

    Google Scholar 

  12. Grüneberg, Th.: Keratosis follicularis et parafollicularis serpiginosa. Hautarzt7, 150–156 (1956)

    Google Scholar 

  13. Hauss, H.: Keratosis follicularis serpiginosa Lutz (Elastoma intrapapillare perforans verruciforme Miescher) und Hyperkeratosis follicularis et parafollicularis in cutem penetrans Kyrle. Derm. Wschr.147, 550–562 (1963)

    Google Scholar 

  14. Hitch, J. M., Raleigh, N. N., Lund, H. Z.: Elastosis perforans serpiginosa. Arch. Derm.79, 407–421 (1959)

    Google Scholar 

  15. Kanan, M, W.: Familial reactive perforating collagenosis and intolerance to cold. Brit. J. Derm.91, 405–414 (1974)

    Google Scholar 

  16. Korting, G. W.: Elastosis perforans serpiginosa als ektodermales Randsymptom bei Cutis laxa. Arch. klin. exp. Derm.224, 437–446 (1966)

    Google Scholar 

  17. Kyrle, J.: Hyperkeratosis follicularis et parafollicularis in cutem penetrans. Arch. Derm. Syph.123, 466–493 (1916)

    Google Scholar 

  18. Lever, W. F.: Histopathology of the skin. 5th Ed. pp. 314–317. Philadelphia-Toronto: J. P. Lippincott Co. 1975

    Google Scholar 

  19. Lutz, W.: Keratosis follicularis serpiginosa. Dermatologica (Basel)106, 318–320 (1953)

    Google Scholar 

  20. Malak, J. A., Kurban, A. K.: “Catharsis”: An excretory function of the epidermis. Brit. J. Derm.84, 516–522 (1971)

    Google Scholar 

  21. Mehregan, A. H.: Transepithelial elimination. Curr. Probl. Derm. Vol. 3, pp. 114–147 Basel-München-Paris-New York: Karger 1970

    Google Scholar 

  22. Mehregan, A. H.: Elastosis perforans serpiginosa. Arch. Derm.97, 381–393 (1968)

    Google Scholar 

  23. Mehregan, A. H., Coskey, R. J.: Perforating folliculitis. Arch. Derm.97, 394–399 (1968)

    Google Scholar 

  24. Mehregan, A. H., Schwartz, O. D., Livingood, C. S.: Reactive perforating collagenosis. Arch. Derm.96, 177–182 (1967)

    Google Scholar 

  25. Meves, C., Vogel, A.: Elektronenmikroskopische Untersuchungen an einem Fall von Elastosis perforans serpiginosa. Dermatologica (Basel)145, 210–221 (1973)

    Google Scholar 

  26. Miescher, G.: Elastoma intrapapillare perforans verruciforme. Dermatologica (Basel)110, 254–266 (1955)

    Google Scholar 

  27. Montagna, W., Parakkal, P. F.: The structure and function of the skin. pp. 132–135. New York-London: Academic Press 1974

    Google Scholar 

  28. Nair, B. K. H., Sarojini, P. A., Basheer, A. M., Nair, C. H. K.: Reactive perforating collagenosis. Brit. J. Derm.91, 399–403 (1974)

    Google Scholar 

  29. Niebauer, G., Stockinger, L.: Über die senile Elastose. Arch. klin. exp. Derm.221, 122–143 (1965)

    Google Scholar 

  30. Owens, D. W., Freeman, R. G.: Perforating granuloma annulare, Arch. Derm.103, 65–67 (1971)

    Google Scholar 

  31. Pass, F., Goldfischer, S., Sternlieb, J., Scheinberg, I. H.: Elastosis perforans serpiginosa during penicillamin therapy for Wilson's disease. Arch. Derm.108, 713–715 (1973)

    Google Scholar 

  32. Pinkus, H.: “Biology of epidermal cells” pp. 597–598. In: Rothman, S., Physiology and biochemistry of the skin. Chicago: University of Chicago Press, 1954

    Google Scholar 

  33. Pinkus, H., Mehregan, A. H.: The primary histologic lesion of seborrheic dermatitis and psoriasis. J. invest. Derm.46, 109–116 (1966)

    Google Scholar 

  34. Streitmann, B.: Ein Beitrag zu den das Follikelepithel durchbrechenden Prozessen. Z. Haut-u. Geschl.-Kr.45/5, 195–200 (1970)

    Google Scholar 

  35. Sweet, R. D.: Orientations. Transactions and annual report of the St. John's Hospital. Derm. Soc.57, 135–138 (1971)

    Google Scholar 

  36. Tapernoux, B., Delacrétaz, J.: Hyperkératose “en bouchons” d'origine mécanique. Dermatologica (Basel)143, 201–208 (1971)

    Google Scholar 

  37. Weiner, A. L.: Reactive perforating collagenosis. Arch. Derm.102, 540–544 (1970)

    Google Scholar 

  38. Weiner, J.: Kyrle's disease in siblings. Arch. Derm.95, 329–332 (1967)

    Google Scholar 

  39. Whyte, H. J., Winkelmann, R. K.: Elastosis perforans (perforating elastosis). J. invest. Derm.35, 113–122 (1960)

    Google Scholar 

  40. Woringer, F., Laugier, P.: Collagenoma perforans verruciforme. Derm. Wschr.3, 64–68 (1963)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. II. Univ. Hautklinik, Wien, Alserstraße 4, A-1090, Wien, Germany

    H. Bardach

Authors
  1. H. Bardach
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bardach, H. Dermatosen mit transepithelialer perforation. Arch. Derm. Res. 257, 213–226 (1976). https://doi.org/10.1007/BF00558095

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00558095

Keywords

Search

Navigation