Summary
Ultrastructure study of specimens taken from 3 patients with cutaneous Leishmaniasis showed parasites within macrophages. None were found in extracellular locations. Within the macrophages cytoplasm, parasites were located either lying free in the cytoplasm or inside intracytoplasmic vacuoles.
Parasites in various stages of degeneration were found both lying free in the cytoplasm or within vacuoles.
The parasite-macrophage relationship and the mechanism by which the host reacts toward the parasite are discussed.
Zusammenfassung
Die elektronenmikroskopischen Untersuchungen von 3 Patienten mit cutaner Leishmaniasis zeigten die Parasiten innerhalb der Makrophagen. Keime wurden extracellulär aufgefunden. Innerhalb des Cytoplasmas der Makrophagen lagen die Parasiten entweder frei im Cytoplasma oder innerhalb intracytoplasmatischer Vakuolen.
Die Parasiten werden in verschiedenen Degenerationsformen im Cytoplasma oder in den Vakuolen aufgefunden.
Die Beziehung zwischen den Parasiten und den Makrophagen einschließlich der Reaktionsmechanismen des Wirts gegen den Parasiten wurden diskutiert.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anton-Lamprecht, I.: Intracellulare Geißeln in Epidermizellen menschlicher Haut. Arch. Derm. Forsch.243, 199–208 (1972)
Armstrong, J. A., D'Arcy Hart, P.: Response of cultured macrophages to mycrobacterium tuberculosis with observation on fusion of phagosomes with lysosomes. J. Exp. Med.134, 713–740 (1971)
Farah, F. S., Malak, J. A.: Cutaneous leishmaniasis. Arch. Derm.103, 467–474 (1971)
Farah, F. S., Samra, S. A., Nowayri-Salt, N.: The role of the macrophage in cutaneous leishmaniasis. Immunology29, 755–764 (1975)
Garnham, P. C. C.: The genus leishmaniasis. Bull. WHO44, 477–489 (1971)
Hart, P. D., Armstrong, J. A.: Ultrastructural study of the behaviour of macrophages toward parasitic mycobacteria. Infect. Immun.5, 803–807 (1972)
Jones, T. C., Hirsch, J. G.: The interaction between toxoplasma Gondii and Mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J. Exp. Med.136, 1173–1194 (1972)
Kress, Y., Bloom, B. R.: Resistance of trypanosoma Cruzi to killing by macrophages. Nature (Lond.)257, 394–396 (1975)
Kurban, A. K., Malak, J. A., Farah, F. S.: Histopathology of cutaneous leishmaniasis. Arch. Derm.93, 396–401 (1966)
Mauel, J., Behin, R., Biroum-Neoryasin, Doyle, J. J.: Survival and death of leishmania in macrophages. In: Parasites in the Immunized Host: mechanism of Survival. pp. 225–238. Ciba Foundation Symposium 25. Amsterdam: Elsevier 1974
Molyneux, D. H.: Virus like particles in leishmania parasite. Nature (Lond.)249, 588 (1974)
Peters, W.: Drug resistance in trypanosomiasis and leishmaniasis. In: Trypanosomiasis and Leishmaniasis. pp. 309–326. A Ciba Foundation Symposium. Amsterdam: Elsevier 1974
Reynolds, E. S., Treiman-Moslem, M., Szabo, S.: Hepatoxicity of vinyl c chloride and dichloriethylene. Amer. J. Path.81, 219 (1975)
Scherft, J. P., Daems, W. T.: Single cilia in chondrocytes. J. Ultrast. Res.19, 546 (1967)
Vickerman, K.: The ultrastructure of pathogenic flagellates. In: Trypanosomiasis and Leishmaniasis. pp. 171–190. A Ciba Foundation Symposium. Amsterdam: Elsevier 1974
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sandbank, M. Cutaneous leishmaniasis. Arch. Derm. Res. 257, 195–201 (1976). https://doi.org/10.1007/BF00558093
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00558093