Archives of Dermatological Research

, Volume 253, Issue 1, pp 43–51 | Cite as

Studies on the role of C-type viruses in the development of epithelial tumors induced with DMBA

  • Wojciech Maciejewski
  • Jan Dąbrowski
  • Stefania Jabłńska


Epithelial tumors were induced using 0.5% solution of DMBA in two strains of mice—one infected with leukoviruses (Swiss mice), and the other free of these viruses (hairless mice). Tumors from 15 mice of each strain were examined light- and electron-microscopically. Depending on the period of administration of the carcinogen, benign growths of the type of papilloma or keratoacanthoma were obtained, or malignant tumors. In the tumors in Swiss mice electron microscopy revealed a distinct increase in the numbers of viruses in comparison with surrounding skin and intact skin of healthy mice of this strain. In spite of certain histologic differences between tumors produced in Swiss and hairless mice, the results argue against a role of leukoviruses in the pathogenesis of experimentally induced epithelial tumors in mice.


Papilloma Epithelial Tumor DMBA Swiss Mouse Hairless Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Epitheliale Tumoren wurden mittels einer 0,5%igen DMBA-Lösung bei 2 Mäusestämmen — einer war infiziert mit Leukoviren (weiße Mäuse vom Swiss-Stamm), der zweite war virusfrei (haarlose Mäuse) — induziert.

Die Tumoren wurden bei 15 Mäusen beider Stämme im Licht- und Elektronenmikroskop untersucht. Abhängig von der Anwendungsperiode des Carcinogens erzielte man benigne Tumoren vom Papillom- und Keratoacanthomtyp oder maligne Tumoren.

Bei den in virusfreien Mäusen erzielten Tumoren zeigten elektronenmikroskopische Untersuchungen ein stärkeres Wachstum der Viren im Verhältnis zur unveränderten Haut in der Tumorumgebung und der gesunden Kontrollmäuse desselben Stammes.

Ungeachtet gewisser histologischer Unterschiede zwischen den Tumoren, induziert bei Mäusen des mit Viren infizierten Stammes und bei haarlosen Mäusen, sprechen die Untersuchungen gegen die Rolle von Leukoviren bei der Pathogenese von experimentellen epithelialen Tumoren bei Mäusen.


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Wojciech Maciejewski
    • 1
  • Jan Dąbrowski
    • 1
  • Stefania Jabłńska
    • 1
  1. 1.Department of DermatologyWarsaw Medical AcademyPoland

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