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Evidence for a T-cell reaction in the cutaneous sarcoid granuloma

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Summary

In cutaneous sarcoidosis, mononuclear cells of granuloma have been freed and characterized by immunological tests. Of these cells, 84% of them were found to be T dependent by the E rosette test. A similar value (79%) was obtained in the stroma of delayed hypersensitivity reaction, whose immunological functions are well known. However, the physiological role of the thymus dependent pupulation within granulomas must be established.

Zusammenfassung

Mononukleare Zellen von Granulomen bei cutaner Sarkoidose wurden isoliert und durch immunologische Tests charakterisiert.

84% dieser Zellen wurden durch den Rosettentest den T-Zellen zugeordnet. Ein etwa gleicher Prozentsatz (79%) wurde im Gewebe mit allergischer Spätreaktion beobachtet, deren immunologische Typisierung und Funktion gut bekannt ist. Die Rolle der thymusabhängigen Zellpopulation in Granulomen bedarf jedoch weiterer Untersuchungen.

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Authors and Affiliations

  1. Laboratory of Immunopathology and Dermatological Research, Edouard Herriot Hospital, Place d'Arsonval, F-69374, Lyon-Cedex 2, France

    A. Alario, J. Viac & J. Thivolet

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  1. A. Alario
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  2. J. Viac
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  3. J. Thivolet
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Alario, A., Viac, J. & Thivolet, J. Evidence for a T-cell reaction in the cutaneous sarcoid granuloma. Arch. Derm. Res. 259, 135–140 (1977). https://doi.org/10.1007/BF00557953

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