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European Journal of Clinical Pharmacology

, Volume 27, Issue 5, pp 583–587 | Cite as

Pharmacokinetics of propranolol during pregnancy

  • M. F. O'Hare
  • C. D. Kinney
  • G. A. Murnaghan
  • D. G. McDevitt
Originals

Summary

Propranolol, a beta-adrenoceptor blocking drug, was administered to 6 healthy pregnant volunteers between 32 and 36 weeks gestation and when at least 6 weeks postparum. On both occasions, subjects were given propranolol 120 mg orally or 10 mg intravenously in randomised order with a minimum washout period of 1 week. Propranolol was assayed in plasma by gas-liquid chromatography with electron-capture detection and the pharmacokinetic parameters were investigated. There were no significant alterations in elimination half-life, clearance or apparent volume of distribution per kilogram antenatally compared with postnatally: bioavailability was also unchanged. It is concluded that the disposition of propranolol is not altered during pregnancy.

Key words

propranolol pregnancy beta-adrenoceptor antagonist pharmacokinetics 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • M. F. O'Hare
    • 1
  • C. D. Kinney
    • 1
  • G. A. Murnaghan
    • 1
  • D. G. McDevitt
    • 1
  1. 1.Departments of Midwifery and Gynaecology, Therapeutics and PharmacologyThe Queen's University of Belfast Royal Maternity HospitalBelfastNorthern Ireland

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