Journal of Molecular Evolution

, Volume 36, Issue 6, pp 596–598 | Cite as

Sequence homology between a bacterial metalloproteinase and eukaryotic matrix metalloproteinases

  • San Jose de Souza
  • Ricardo Brentani
Letters to the editor


The origin and evolution of matrix metalloproteinases represent an exciting subject of study. Recently, various reports have searched for a relationship between bacterial and eukaryotic metalloproteinases. In this report, we constructed a phylogenetic tree using the amino acid sequence of one bacterial metalloproteinase and eight eukaryotic matrix metalloproteinases and performed multiple alignments with some of these sequences. We concluded that there is a familial relationship between members of the four major branches represented in the tree.

Key words

Molecular evolution Metalloproteinase Collagenase 


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Copyright information

© Springer-Verlag New York Inc 1993

Authors and Affiliations

  • San Jose de Souza
    • 1
  • Ricardo Brentani
    • 1
  1. 1.Ludwig Institute for Cancer Sáo Paulo branchSão PauloBrazil

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