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Esterase-25(Es-25): Identification and characterization of a new kidney arylesterase of the house mouse, genetically linked toLy-18 on chromosome 12

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Abstract

Genetic variation of a codominantly inherited kidney esterase, designated ES-25, has been discovered in the house mouse using disc electrophoresis. The ES-25A phenotype was found in A strains, AKR, and BALB/c. ES-25B was found in C57 BL strains and several other laboratory strains. The enzyme was shown to be controlled by a presumed structural locus,Es-25. The high concordance in 48 RI strains ofEs-25 withLy-18 indicated the location ofEs-25 on chromosome 12. The gene orderEs-25—Ly-18—D12Nyu1—Pre-1 was proposed.

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Authors and Affiliations

  1. Pathologisches Institut, Universität Freiburg, D 7800, Freiburg, Bundesrepublik Deutschland

    Otto H. v. Deimling

  2. The Jackson Laboratory, 04609, Bar Harbor, Maine

    Benjamin A. Taylor

Authors
  1. Otto H. v. Deimling
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  2. Benjamin A. Taylor
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Additional information

This is communication No. 57 of a research program devoted to the cellular distribution, genetics, and regulation of nonspecific esterases. The work was supported by the Deutsche Forschungsgemeinschaft (De 315/2-1).

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v. Deimling, O.H., Taylor, B.A. Esterase-25(Es-25): Identification and characterization of a new kidney arylesterase of the house mouse, genetically linked toLy-18 on chromosome 12. Biochem Genet 25, 639–646 (1987). https://doi.org/10.1007/BF00556208

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  • DOI: https://doi.org/10.1007/BF00556208

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