European Journal of Clinical Pharmacology

, Volume 35, Issue 1, pp 77–79 | Cite as

Protective effect of tulobuterol on methacholine-induced bronchospasm in asthmatic children

  • A. Riba
  • R. Dal-Re
  • F. Morell
Short Communications


In a single-blind, placebo-controlled trial 19 asthmatic children aged 10–14 years were studied during a stable phase of the disease. All patients were tested with a methacholine inhalation test on two consecutive days, on the first day after oral administration of a placebo, and on the second day following an oral dose of tulobuterol HCl.

The cumulative methacholine dose required to produce at least a 20% decrease in FEV1 was significantly higher after tulobuterol than after the placebo.

It is concluded that tulobuterol HCl reduces methacholine-induced bronchospasm in children.

Key words

tulobuterol asthma methacholine inhalation children 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. Riba
    • 1
  • R. Dal-Re
    • 2
  • F. Morell
    • 1
  1. 1.Pulmonary Section, General Hospital Vall d'HebronAutonomous UniversityBarcelonaSpain
  2. 2.Medical DepartmentAbbott Laboratories S.A.MadridSpain

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