Abstract
Chronic injections of 2 mg/kg diazepam disrupted both steady-state performance and new discrimination learning in pigeons. However, the time course of disruption differed for each of the two tasks, i.e., steady-state performance was briefly disrupted early, whereas acquisition showed a more persistent delayed disruption. The difference was interpreted as resulting from a dual effect of diazepam on behavior. The early performance disruption was thought to reflect a general nonspecific sedative action of the drug, while the delayed disruption of learning was interpreted as the result of diazepam[s selective interference with acquistion processes. Some support for rapid adjustment to the sedative effects of diazepam was found, but there was no evidence for the development of physiological tolerance to diazepam-induced acquisition deficits.
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References
Barthalmus GT, Leander JD, McMillan DE (1978) Combined effects of ethanol and diazepam on performance and acquisition of serial position sequences by pigeons. Psychopharmacology 59:101–102
Brown P, Jenkins HM (1968) Autoshaping of the pigeon's key peck. J Exp Anal Behav 11:1–8
Cesare DA, McKearney JW (1980) Tolerance to suppressive effects of chlordiazepoxide on operant behavior: Lack of cross-tolerance to pentobarbitol. Pharmacol Biochem Behav 13:545–548
Cooper SJ, Posadas-Andrews A (1979) Food and water intake in the nondeprived pigeon after chlordiazepoxide administration. Psychopharmacology 65:99–101
Cooper SJ, Burnett G, Grown K (1981) Food preference following acute or chronic chlordiazepoxide administration: Tolerance to an antineophobic action. Psychopharmacology 73:70–74
File S (1981) Rapid development of tolerance to the sedative effects of lorazepam and triazolam in rats. Psychopharmacology 73:240–245
Ghoneim MM, Mewaldt SP (1975) Effects of diazepam and scopolamine on storage, retrieval, and organization processes in memory. Psychopharmacologia 44:257–262
Ghoneim MM, Mewaldt SP (1977) Studies on human memory: The interactions of diazepam, scopolamine, and physostigmine. Psychopharmacology 52:1–6
Grimm VE, Hershkowitz M (1981) The effect of chronic diazepam treatment on discrimination performance and3H-flunitrazepam binding in the brains of shocked and nonshocked rats. Psychopharmacology 74:132–136
Iwasaki T, Ezawa K, Iwahara S (1976) Differential effects of chlordiazepoxide on simultaneous and successive brightness discrimination learning in rats. Psychopharmacology 48:75–78
Jensen RA, Martinez JL, Vasquez BJ, McGaugh JL (1979) Benzodiazepines alter acquisition and retention of an inhibitory avoidance response in mice. Psychopharmacology 64:125–126
Liljequist R, Linnoila M, Mattila MJ (1978) Effects of diazepam and chlorpromazine on memory functions in man. Eur J Clin Pharmacol 13:339–343
Patel JB, Ciofalo VB, Iorio LC (1979) Benzodiazepine blockade of passive-avoidance task in mice: A state-dependent phenomenon. Psychopharmacology 61:25–28
Thompson DM, Moerschbaecher JM (1979) Drug effects on repeated acquisition. In: Thompson T, Dews PB (eds) Advances in Behavioral Pharmacology, vol 2. Academic Press, New York, pp 229–259
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Hughes, L.M., Wasserman, E.A. & Hinrichs, J.V. Chronic diazepam administration and appetitive discrimination learning: Acquisition versus steady-state performance in pigeons. Psychopharmacology 84, 318–322 (1984). https://doi.org/10.1007/BF00555206
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DOI: https://doi.org/10.1007/BF00555206