Abstract
A behavioural model sensitive to manipulation of brain noradrenaline systems and with characteristics of beta-receptor mediation has been developed using the duration of thiopentone anaesthesia in the rat. Acute and chronic administration of various antidepressant agents was examined. In the acute phase, (30 min prior to thiopentone) the noradrenaline uptake-inhibiting tricyclic drugs and viloxazine increased anaesthesia duration in a dose-dependent fashion. The atypical antidepressants trazodone, iprindole, and mianserin did this only weakly, while the dopaminergic and serotonergic uptake-inhibiting antidepressants (respectively bupropion, nomifensine, and zimelidine, fluoxetine) markedly shortened anaesthesia duration. Chronic administration (for 15 days) prolonged anaesthesia duration measured 2 or 5 days after the last drug injection for all tricyclic agents, for the atypical antidepressants mianserin, iprindole, fluoxetine, and zimelidine, and for viloxazine.
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References
Buckett WR, Luscombe GP (1983) Dothiepin and desipramine induce different changes in noradrenergic and serotonergic behaviour after subchronic treatment. Br J Pharmacol (in press)
Clements-Jewry S (1978) The development of cortical β-adrenoceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserin. Neuropharmacology 17:779–781
Denber HCB (1975) Pharmacology of depression. In: Denber HCB, Dekker M (eds) Psychopharmacological treatment —theory and practice. New York
Fludder JM, Leonard BE (1979) The effects of amitriptyline, mianserin, phenoxybenzamine and propranolol on the release of noradrenaline in the rat brain in vitro. Biochem Pharmacol 28:2333–2336
Gandolfi O, Barbaccia ML, Chuang DM, Costa E (1983) Daily bupropion injections for 3 weeks attenuate the NE-stimulation of adenylate cyclase and the number of β-adrenergic recognition sites in the frontal cortex. Neuropharmacology 22:927–929
Green AR, Nutt DJ (1983) Antidepressants. In: Grahame-Smith DG, Cowen PJ (eds) Psychopharmacology. Part I Preclinical psychopharmacology. Excerpta Medica, Amsterdam
Iversen LL (1967) The uptake and storage of noradrenaline in sympathetic nerves. Cambridge University Press
Janowsky AJ, Steranka LL, Gillespie DD, Sulser F (1982) Role of neuronal signal input in the down-regulation of central noradrenergic receptor function by antidepressant drugs. J Neurochem 39:290–292
Koe BK (1976) Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J. Pharmacol Exp Ther 199:649–661
Koe BK (1983) A common mechanism of action for antidepressant drugs? 4:110
McRae-Degueurce A, Berod A, Mermet A, Keller A, Chouvet G, Joh TH, Pujol JF (1982) Alterations in tyrosine hydroxylase activity elicited by raphe nuclei lesions is the rat locus coeruleus: evidence for the involvement of serotonergic afferents. Brain Res 235:285–301
Mason ST, Angel A (1983a) Behavioural evidence that chronic treatment with the antidepressant desipramine causes reduced functioning of brain noradrenaline systems. Psychopharmacology 81:73–77
Mason ST, Angel A (1983b) Anaesthesia: the role of adrenergic mechanisms. Eur J Pharmacol 91:29–39
Mason ST, Angel A (1983c) Brain noradrenaline and anaesthesia: further characterization of the beta-receptor. Neuropharmacology 9:1065–1069
Mason ST, King RAJ, Banks P, Angel A (1983) Brain noradrenaline and anaesthesia: behavioural and electrophysiological evidence. Neuroscience 10:177–185
Mishra R, Janowsky A, Sulser F (1980) Action of mianserin and zimelidine on the norephinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding. Neuropharmacology 19:983–987
Neilsen M, Braestrup C (1977a) Desipramine and some other antidepressant drugs decrease the major norephinephrine metabolite 3, 4-dihydroxy-phenylglycolsulphate in the rat brain. Naunyn-Schmiedeberg's Arch Pharmacol 300:93–99
Neilsen M, Braestrup C (1977b) Chronic treatment with desipramine caused a sustained decrease of 3, 4-dihydroxyphenylglycol-sulphate in the rat brain. Naunyn-Schmiedeberg's Arch Pharmacol 300:87–92
Nyback HV, Walters JR, Aghajanian GK, Roth RH (1974) Noradrenergic neurons: effects of tricyclic antidepressants on single unit activity. Pharmacologist 16:236
Nyback HV, Walters JR, Aghajanian GK, Roth RH (1975) Tricyclic antidepressants: effects on the firing of brain noradrenaline neurons. Eur J Pharmacol 32:302–312
Racagni G, Mocchetti I, Calderini G, Battistella A, Brunello N (1983) Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: receptor desensitization and neurotransmitter interactions. Neuropharmacology 22:415–424
Rosloff BN, Davis JM (1978) Decrease in brain NA turnover after chronic DMI treatment: no effect of iprindole. Psychopharmacology 56:335–341
Ross SB, Renyi AL (1977) Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat by (2)- and (E)-3-4-(4-bromophenyl) N,N-dimethyl-e(3-pyridyl)allylamine and their secondary analogues. Neuropharmacology 16:57–63
Ross SB, Renyi AL, Ogren SO (1971) A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices. Life Sci 10:1267–1277
Schweitzer JW, Schwartz R, Friedhoff AJ (1979) Intact presynaptic terminals required for beta-adrenergic receptor regulation by desipramine. J Neurochem 33:377–379
Scuvee-Moreau J, Fischer P, Dresse A (1978) Effect of tricyclic antidepressant drugs on spontaneous activity of noradrenergic neurons. Arch Int Pharmacodyn Ther 234:344
Sheard MH, Zolovick A, Aghajanian GK (1972) Raphe neurons: effect of tricyclic antidepressant drugs. Brain Res 43:690–694
Sugrue MF (1981) Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain MHPG content. Life Sci 28:377–384
Sulser F, Mobley PL (1981) Regulation of central noradrenergic receptor function: New vistas on the mode of action of antidepressant treatments. In: Usdin E, Davis JM, Bunney WE (eds) Neuroregulators: basic and clinical frontiers: Chichester, John Wiley & Sons
Svensson TH, Usdin T (1978) Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation. Science 202:1089–1901
Svensson TH, Usdin T (1979) In: Usdin E, Kopin IJ, Barchas J (eds) Catecholamines: basic and clinical frontiers. Pergamon, New York
Vetulani J, Stawarz RJ, Sulser F (1976) Adaptive mechanism of the noradrenergic cyclic AMP generating system in the limbic forebrain of the rat: adaptation to persistent changes in the availability of norephinephrine. J Neurochem 27:661–666
Wolfe BB, Harden TK, Sporn JR, Molinoff PB (1978) Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants. J Pharmacol Exp Ther 207:446–457
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Mason, S.T., Angel, A. Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model. Psychopharmacology 84, 304–309 (1984). https://doi.org/10.1007/BF00555203
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DOI: https://doi.org/10.1007/BF00555203