Biochemical Genetics

, Volume 28, Issue 1–2, pp 57–68 | Cite as

Genetic variation and biochemical properties of esterase-18 (ES-18) in the laboratory rat (Rattus norvegicus): A new locus of esterase cluster 2 in linkage group V

  • Reinhart Kluge
  • Hans J. Hedrich
  • Otto von Deimling


A new liver-specific rat carboxylesterase isozyme (EC designated esterase-18 (ES-18) is described. Genetic variation of ES-18 was examined in 93 inbred strains and substrains and a structural locusEs-18 was suggested, coding for either the presence (Es-18a) or the absence (Es-18b) of the isozyme. Linkage studies involving two backcross series revealed thatEs-18 resides in cluster 2 of LGV. No recombination betweenEs-18 and other cluster 2 loci was found in 19 lines of two RI strain sets or in the backcross series.

Key words

esterase-18 rat genetics liver specific linkage group V cluster 2 


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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Reinhart Kluge
    • 1
  • Hans J. Hedrich
    • 2
  • Otto von Deimling
    • 3
  1. 1.Abteilung für Versuchstierkunde der Medizinischen Fakultät der RWTH AachenAachenBundesrepublik Deutschland
  2. 2.Zentralinstitut für VersuchstierzuchtHannoverBundesrepublik Deutschland
  3. 3.Pathologisches Institut, Abteilung für Chemische PathologieUniversität Freiburg i.Br.FreiburgBundesrepublik Deutschland

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