Urological Research

, Volume 2, Issue 2, pp 61–68 | Cite as

Renal clearance studies in the pig

Surgical procedures, performance of investigations and physiological data
  • B. Fåhraeus
  • R. Lorentzon


The pig, especially the miniature pig, has in recent years been used increasingly frequently as a laboratory animal and experience shows that as such it is very useful in many circumstances. The aim of the present investigation was to study the renal function in unsedated and unrestrained pigs. Techniques for the implantation of central venous catheters, for cystostomy, for thyroidectomy and for open kidney biopsy are described. Implantation of central venous catheters and cystostomy are necessary procedures for making clearance studies in unsedated and unrestrained pigs possible. The following mean values for the renal function were obtained: ClIn 4.11 ml/min/kg, Cl51Cr-EDTA-p 3.82 ml/min/kg, Cl51Cr-EDTA-w.b. 3.89 ml/min/kg, ClPAH 21.4 ml/min/kg, Cl125I-hippuran 17.4 ml/min/kg, TmPAH 4.31 mg/min/kg and TRP over 80%.

Key words

Clearance studies serum electrolytes pigs 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • B. Fåhraeus
    • 1
    • 2
  • R. Lorentzon
    • 1
    • 2
  1. 1.Department of UrologyUniversity of UmeåSweden
  2. 2.Department of Clinical ChemistryUniversity of UmeåSweden

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