Biochemical Genetics

, Volume 25, Issue 7–8, pp 603–610 | Cite as

A gene (Bmn) controllingβ-mannosidase activity in the mouse is located in the distal part of chromosome 3

  • Lars-G. Lundin


A gene (Bmn) with a major effect on β-mannosidase activity in kidney and liver of the house mouse was revealed by assay with the synthetic substratep-nitrophenyl-β-d-mannoside. Activity is low in DBA/2J and CSB mice and high in C57BL/6J mice. By the use of the BXD series of recombinant inbred strains and by crosses between C57BL and CSB, it was possible to map the gene to the distal part of chromosome 3 by demonstration of linkage to a gene for cadmium resistance,cdm, as well as to theAdh-3 locus.

Key words

mouse β-mannosidase genetic linkage recombinant inbred strains 


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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Lars-G. Lundin
    • 1
  1. 1.Department of Medical & Physiological ChemistryUppsalaSweden

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