Genetic and synteny mapping of parathyroid hormone and beta hemoglobin in cattle
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Parathyroid hormone and the beta hemoglobin gene cluster, which are closely linked on human chromosome 11p15, were localized to bovine syntenic group (U7) with the gene for catalase by the use of bovine × hamster hybrid somatic cells. Restriction fragment length polymorphisms (RFLPs) were followed through informative pedigrees to determine a linkage map distance of 15.6±5.4 cM between the parathyroid hormone and hemoglobin genes. Allelic frequencies of the DNA fragment were compared in a small sampling of cattle from five different breeds.
Key wordscattle gene mapping parathyroid hormone beta hemoglobin catalase restriction fragment length polymorphism
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- Antonarakis, S. E., Phillips, J. A., III, Mallonee, R. L., Kazazian, H. H., Jr., Fearon, E. R., Waber, P. G., Kronenberg, H. M., Ullrich, A., and Meyers, D. A. (1983). Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man.Proc. Natl. Acad. Sci. USA 806615.PubMedGoogle Scholar
- Lalley, P. A., Sakaguchi, A. Y., Eddy, R. L., Honey, N. H., Bell, G. I., Shen, L.-P., Rutter, W. J., Jacobs, J. W., Heinrich, G., Chin, W. W., and Naylor, S. L. (1987). Mapping polypeptide hormone genes in the mouse: Somatostatin, glucagon, calcitonin, and parathyroid hormone.Cytogenet. Cell Genet. 4492.PubMedGoogle Scholar
- Levan, G., Szpirer, J., Szpirer, C., and Yoshida, M. C. (1986). Gene map of the rat.Rat. Newslett. 173.Google Scholar