Cancer Chemotherapy and Pharmacology

, Volume 14, Issue 1, pp 30–33 | Cite as

Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil

  • Takashi Tsuruo
  • Harumi Iida
  • Fusao Makishima
  • Takao Yamori
  • Hironori Kawabata
  • Shigeru Tsukagoshi
  • Yoshio Sakurai
Original Articles Verapamil, Tumor Metastasis


Verapamil, a calcium antagonist, inhibited both experimental (IV inoculation of tumor cells) and spontaneous metastasis (SC inoculation) of the highly metastatic B16 melanoma and colon adenocarcinoma 26 cell lines. Verapamil treatment resulted in a maximum 80% inhibition of metastases, the degree of inhibition varying among the different metastatic systems. Verapamil inhibited platelet aggregation induced by these tumor cell lines, the patterns of inhibition being different for B16 melanoma and colon adenocarcinoma. The inhibition of platelet aggregation induced by tumor cells is proposed as a mechanism by which the calcium antagonist exerts its antime-tastatic effect. These results, together with our previous findings that calcium antagonists can increase the cytotoxicity of drugs in tumor cells with induced or inherent drug resistance by inhibiting outward transport of the drug, indicate that calcium antagonists have potential as a new class of adjuvant agents in the field of cancer chemotherapy.


Tumor Cell Verapamil Platelet Aggregation Tumor Cell Line Calcium Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Takashi Tsuruo
    • 1
  • Harumi Iida
    • 1
  • Fusao Makishima
    • 1
  • Takao Yamori
    • 1
  • Hironori Kawabata
    • 1
  • Shigeru Tsukagoshi
    • 1
  • Yoshio Sakurai
    • 1
  1. 1.Cancer Chemotherapy CenterJapanese Foundation for Cancer ResearchTokyoJapan

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