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European Journal of Clinical Pharmacology

, Volume 27, Issue 4, pp 505–507 | Cite as

Evaluation of visual function in healthy subjects after administration of Ro 15-1788

  • Y. Lupolover
  • A. B. Safran
  • D. Desangles
  • C. de Weisse
  • J. J. Meyer
  • A. Bousquet
  • A. Assimacopoulos
Short Communications

Summary

Ro 15-1788 is a specific benzodiazepine antagonist, which has also been shown to have some agonist properties. Since benzodiazepine receptors are involved in the physiological mechanisms of vision, a possible intrinsic effect of Ro 15-1788 was sought in 6 healthy volunteers by study of psychophysical flicker thresholds, including critical fusion frequency and low frequency modulation threshold, and pattern reversal visual evoked response, using double blind cross-over methodology. In each session 2 tablets of Ro 15-1788 30 mg were administered. Using a two factorial univariate analysis of variancé, no change was detected in any of the parameters studied.

Key words

benzodiazepine antagonist visual function intrinsic effect Ro 15-1788 healthy volunteers 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Y. Lupolover
    • 1
  • A. B. Safran
    • 1
  • D. Desangles
    • 1
  • C. de Weisse
    • 1
  • J. J. Meyer
    • 2
  • A. Bousquet
    • 2
  • A. Assimacopoulos
    • 3
  1. 1.Clinique d'OphtalmologieGenevaSwitzerland
  2. 2.Institut de Médecine Préventive et SocialeGenevaSwitzerland
  3. 3.Division d'Informatique MédicaleHôpital Cantonal UniversitaireGenevaSwitzerland

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