Summary
By means of scanning electron microscope “en face” examination of aortic intimal surface, two phases are recognizable in the development of experimental cholesterol atherosclerosis in the guinea-pig. During the first phase, after about two months of hypercholesterolic diet, no intimal plaques are to be found, and an amorphous substance (fibrin? — lipoproteins?) is deposited as a diffuse covering of wide areas of the aortic intimal surface along with erythrocytes and platelets. During this first phase, localized “flattenings” of the intimal folds are also evident.
It is only during the second phase (after about four months) that intimal plaques become recognizable, forming at the bottom of these scattered flattenings, while the diffuse amorphous deposit of the first phase begins to disappear.
Zusammenfassung
Mit Hilfe des Raster-Elektronen-Mikroskopes wurde die Oberfläche der Intima der Aorta von Meerschweinchen, welche mit cholesterinreicher Diät gefüttert worden waren, von der Fläche her betrachtet. Dabei hat sich gezeigt, daß 2 Stufen der Entwicklung einer Atheromatose unterschieden werden können. Die erste Stufe wird schon nach 2 Versuchsmonaten deutlich, zu einem Zeitpunkt also, zu dem im allgemeinen eigentliche Plaques noch nicht nachweisbar sind. Dabei findet sich eine schlierige Substanz, welche der Intime aufliegt, und die wahrscheinlich aus Lipoproteinen, möglicherweise aus Fibrin besteht und die Erythrocyten und Thrombocyten enthält. Diese erste Stufe wird auch durch beschränkte Intima-Plicae-Glättungen gekennzeichnet. In der zweiten Entwicklungsstufe entstehen echte Intimaplatten.
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Weber, G., Tosi, P. Observations with the scanning electron microscope on the development of cholesterol aortic atherosclerosis in the guinea-pig. Virchows Arch. Abt. A Path. Anat. 353, 325–332 (1971). https://doi.org/10.1007/BF00549045
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DOI: https://doi.org/10.1007/BF00549045