Theoretica chimica acta

, Volume 53, Issue 2, pp 175–181 | Cite as

The molecular electrostatic potential of the B-DNA helix

IV. C8 and amino sites of purines and the binding of carcinogenic acetylaminofluorene to DNA
  • Richard Lavery
  • Bernard Pullman
Original Investigations


The influence of a single and double helical DNA environment on the molecular electrostatic potentials at the C8 and amino sites of guanine and adenine are studied. The results are employed in a tentative explanation of the variation in binding sites of N-acetoxy-N-2-acetylaminofluorene with DNA, following whether the nucleic acid is in a native or denatured state.

Key words

B-DNA helix Acetylaminofluorene, carcinogenic, binding of ∼ to DNA 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Richard Lavery
    • 1
  • Bernard Pullman
    • 1
  1. 1.Laboratoire de Biochimie Théorique associé au C.N.R.S.Institut de Biologie Physico-ChimiqueParisFrance

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