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Effect of oxprenolol and metoprolol on serum lipid concentration

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Summary

The aim of the present study was to evaluate whether a reduction in HDL-cholesterol is peculiar to non cardioselective beta blockers or whether it is also produced by cardioselective beta1-blockers. 16 patients with primary arterial hypertension on a balanced isocaloric diet were given oxprenolol 120 to 240 mg/day or metoprolol 100 to 200 mg/day in a random cross-over study. No significant change was observed after either treatment in fasting blood glucose, serum total cholesterol and triglycerides. HDL-cholesterol concentration was significantly decreased on metoprolol, from 41 to 36 mg/dl (p<0.05), while oxprenolol did not affect it at all. The difference might depend on intrinsic sympathomimetic activity which is possessed by oxprenolol and which metoprolol lacks.

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Authors and Affiliations

  1. Institute of Internal Medicine and Metabolic Diseases, Clinica Medica II, II Medical School, University of Naples, Naples, Italy

    L. A. Ferrara, T. Marotta, A. Scilla, P. Mastranzo, P. Strazzullo & M. Mancini

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  1. L. A. Ferrara
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  2. T. Marotta
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  3. A. Scilla
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  4. P. Mastranzo
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  5. P. Strazzullo
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  6. M. Mancini
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Ferrara, L.A., Marotta, T., Scilla, A. et al. Effect of oxprenolol and metoprolol on serum lipid concentration. Eur J Clin Pharmacol 26, 331–334 (1984). https://doi.org/10.1007/BF00548763

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  • DOI: https://doi.org/10.1007/BF00548763

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