Summary
In a multicentre, double-blind, crossover, placebo-controlled study, the antihypertensive effect of labetalol 100 mg and chlorthalidone 10 mg, given alone or in combination, has been assessed in 32 hypertensive patients. The combination had a greater effect in reducing blood pressure than did its separate components. This was particularly evident after exercise. Heart rate increased during chlorthalidone therapy, decreased during labetalol therapy, and a summation effect was observed during treatment with the combination. In most cases additivity was observed, as no interaction between the single components was observed, except for heart rate after exercise, and for diastolic blood pressure in the upright position. No interaction was observed either in the biochemical indices or in the clinical side-effects.
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References
Dollery CT, Bulpitt CJ (1977) Management of hypertension. In: Genest J, Koiw E, Kuchel O (ed) Hypertension. McGraw-Hill, New York, pp 1038–1067
Brittain RT, Levy GP (1976) A review of the animal pharmacology of labetalol, a combined α and β adrenoceptor blocking drug. Br J Clin Pharmacol 3: 681–694
Richards DA, Prichard BNC (1979) Clinical pharmacology of labetalol. Br J Clin Pharmacol 8: 89S-93S
Beermann B, Groschinsky-Grind M (1980) Clinical Pharmacokinetics of diuretics. Clin Pharmacokinet 5: 221–245
Master AM (1935) The two-step test of myocardial function. Am Heart J 10: 495–510
Edwards AL (1970) Experimental design in psychological research. Holt, London, pp 455
Vaughan ED, Carey RM, Peach MJ, Ackerly JA, Ayers CR (1978) The renin response to diuretic therapy. A limitation of antihypertensive potential. Circ Res 42: 691–698
Leonetti G, Terzoli L, Sala C, Bianchini C, Sernesi L, Zanchetti A (1978) Relationship between the hypotensive and renin-stimulating actions of diuretic therapy in hypertensive patients. Clin Sci Mol Med 55: 307S-309S
Trust PM, Rosei EA, Brown JJ, Fraser R, Lever AF, Morton JJ, Robertson JIS (1976) Effects of blood pressure, angiotensin II and aldosterone concentrations during treatment of severe hypertension with intravenous labetalol: comparison with propranolol. Br J Clin Pharmacol 3(4): 799–803
Fagard R, Amery A, Reybrouck T, Lijnen P, Billiet L (1978) Effects of labetalol on systemic and pulmonary haemodynamics at rest and during exercise in hypertensive patients. Clin Sci Mol Med 55: 279S-281S
Tobian L (1967) Why do thiazide diuretics lower pressure in essential hypertension? Annu Rev Pharmacol 7: 399–408
Aoki VS, Brody J (1969) The effect of thiazide on the sympathetic nervous system of hypertensive rats. Arch Int Pharmacodyn Ther 177: 423
Muiesan G, Magnani B, Agabiti-Rosei E, Alicandri C, Ambrosioni E, Miele M (1976) Evaluation of the effect of timolol alone and in combination with hydrochlorothiazide and amiloride in the treatment of mild to moderate arterial hypertension: a double-blind, controlled study. Clin Sci Mol Med 51: 529S-531S
Bateman DN, Dean CR, Mucklow JC, Bulpitt C, Dollery CT (1979) Atenolol and chlorathalidone in combination for hypertension. Br J Clin Pharmacol 7: 357–363
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Lechi, A., Pomari, S., Berto, R. et al. Clinical evaluation of labetalol alone and combined with chlorthalidone in essential hypertension: A double-blind multicentre controlled study. Eur J Clin Pharmacol 22, 289–293 (1982). https://doi.org/10.1007/BF00548395
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DOI: https://doi.org/10.1007/BF00548395