Virchows Archiv A

, Volume 354, Issue 2, pp 150–160 | Cite as

Studies on the healing of arterial lesions in experimental hypertension

I. An electron microscopy study on the healing process of intimal fibrinoid degeneration in hypertensive rats
  • Masayasu Kojimahara
  • Kazuo Sekiya
  • Genju Ooneda


An electron microscopic study was carried out on the healing process of arterial lesions in hypertensive rats; these lesions resemble the plasmatic arterionecrosis seen in human hypertensive intracerebral hemorrhage. Fibrinoid substance deposited in the arterial intima of hypertensive rats disappeared with or without leaving cellulofibrous intimal tissue after continuous administration of antihypertensive drugs. Fibroblast-like smooth muscle cells, endothelial cells, and blood-derived mononuclear cells took part in the healing process of the intimal fibrinoid degeneration; the fibrinoid substance was phagocytosed by fibroblast-like smooth muscle cells and blood mononuclear cells or dissolved by fibroblast-like smooth muscle cells. Hyaline droplets, thought to represent phagocytized fibrinoid substance, were seen in the intimal smooth muscle cells. The cells also participated in the formation of ground substance and collagenous and elastic fibers. These intimal smooth muscle cells are considered to be partly derived from endothelial cells, because they were first found immediately beneath the endothelium during the healing process, because endothelial cells themselves showed myofilaments and fusiform dense bodies, because intimal cells were not found in the normal rat mesenteric arteries, and because degenerative changes were severe in the medial smooth muscle cells.


Smooth Muscle Cell Healing Process Intracerebral Hemorrhage Elastic Fiber Dense Body 
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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Masayasu Kojimahara
    • 1
  • Kazuo Sekiya
    • 1
  • Genju Ooneda
    • 1
  1. 1.Second Department of Pathology, School of MedicineGunma UniversityMaebashiJapan

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