European Journal of Clinical Pharmacology

, Volume 23, Issue 3, pp 235–240 | Cite as

Kinetics of ergotamine after intravenous and intramuscular administration to migraine sufferers

  • J. J. Ibraheem
  • L. Paalzow
  • P. Tfelt-Hansen
Originals

Summary

The kinetics of ergotamine has been investigated in migrainous patients using a new, specific, sensitive HPLC assay (detection limit 100 pg/ml plasma). 10 patients were given ergotamine tartrate 0.5 mg i.v. and 5 of them received the same dose i.m. 2–3 weeks later. Blood samples were collected for up to 54 h following administration and the plasma concentration were analysed. After intravenous administration the plasma ergotamine declined rapidly, with an initial distribution half-life of 3 min followed by a mean terminal half-life of 1.86 h (range 90–155 min). The mean total plasma clearance was 11.0 ml kg−1 min−1, and the volume of distribution (Vdβ) was 1847.6 ml kg−1. Individual t1/2β showed a positive linear correlation with the individual Vdβ. The intramuscular absorption of ergotamine was rapid and maximum plasma levels were usually obtained 10 min following administration. The biological availability was incomplete and variable at 46.6% (range 28.3–60.8%).

Key words

ergotamine pharmacokinetics migraine plasma drug levels i.v. administration i.m. administration bioavailability 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. J. Ibraheem
    • 1
    • 2
  • L. Paalzow
    • 1
    • 2
    • 3
  • P. Tfelt-Hansen
    • 1
    • 2
  1. 1.Department of Pharmacology, Central Research and Control LaboratoryNational Corporation of Swedish PharmaciesSolnaSweden
  2. 2.Department of NeurologyRigshospitaletCopenhagenDenmark
  3. 3.Department of BiopharmaceuticsUniversity of Uppsala Biomedical CenterUppsalaSweden

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