European Journal of Clinical Pharmacology

, Volume 29, Issue 1, pp 21–24 | Cite as

The pharmacodynamics and pharmacokinetics of a new calcium antagonist nisoldipine in normotensive and hypertensive subjects

  • F. Pasanisi
  • P. A. Meredith
  • J. L. Reid


The pharmacodynamic and pharmacokinetic profiles of nifedipine and nisoldipine were compared in a double blind, placebo-controlled study. Nisoldipine, 10 mg significantly reduced systolic blood pressure but nifedipine 20 mg retard did not, although both drugs had significant pharmacodynamic effects as evidenced by increased heart rates. The terminal elimination half-life in plasma was similar for both drugs with a mean of 2 h. The pharmacodynamics of nisoldipine were studied in 8 hypertensives following both acute and chronic administration. Antihypertensive efficacy was demonstrated after acute dosing and was maintained over 4 weeks of twice daily treatment as monotherapy.

Key words

nisoldipine nifedipine pharmacokinetics pharmacodynamics calcium channel blocking drugs hypertension side-effects 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • F. Pasanisi
    • 1
  • P. A. Meredith
    • 1
  • J. L. Reid
    • 1
  1. 1.University Department of Materia MedicaStobhill General HospitalGlasgowScotland

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