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Chemistry of Heterocyclic Compounds

, Volume 23, Issue 4, pp 395–399 | Cite as

Preparation of N-arylamino-2-pyrrolidones from arylhydrazides of γ-chlorobutyric acid

  • A. V. Blokhina
  • V. G. Boronin
  • V. V. Druzhinina
  • V. P. Zhestkov
  • Yu. N. Portnov
Article

Abstract

Intramolecular alkylation of the arylhydrazides of γ-chlorobutyric acid in the presence of sodium ethoxide leads to the formation of N-arylamino-2-pyrrolidones. The direction of the reaction is not altered by the absence of a substituent on the aniline nitrogen atom. In the case of a p-nitrophenyl-hydrazide, O-alkylation is observed.

Keywords

Nitrogen Sodium Organic Chemistry Nitrogen Atom Aniline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • A. V. Blokhina
    • 1
  • V. G. Boronin
    • 1
  • V. V. Druzhinina
    • 1
  • V. P. Zhestkov
    • 1
  • Yu. N. Portnov
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical ChemistryStaraya Kupavna

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