European Journal of Clinical Pharmacology

, Volume 22, Issue 3, pp 273–279 | Cite as

Comparative pharmacokinetic analysis of amoxycillin using open two and three-compartment models

  • A. Dalhoff
  • P. Koeppe


The pharmacokinetic characteristics of amoxycillin were studied in healthy volunteers after intravenous injection of 250 mg, 500 mg and 1,000 mg, and infusion of 2 g and 5 g. Serum concentrations were fitted using either bi- and tri- exponentional equations. Comparison of the regression curves obtained revealed that the three-compartment model gave a better fit to the serum concentration versus time curve. It was evident that there was a third, slow, dose dependent phase of disposition. This result has been confirmed by the fact that the terminal half life of amoxycillin on cessation of a continuous infusion is significantly greater than after acute administration.

Key words

amoxycillin i.v. administration pharmacokinetics two- and three-compartment models 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Dalhoff
    • 1
  • P. Koeppe
    • 2
  1. 1.EssenFederal Republic of Germany
  2. 2.Klinikum Steglitz der Freien Universität BerlinBerlinGermany

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