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European Journal of Clinical Pharmacology

, Volume 22, Issue 3, pp 207–211 | Cite as

Effects of the H2 receptor antagonist ranitidine on anterior pituitary hormone secretion in man

  • G. Delitala
  • L. Devilla
  • A. Pende
  • A. Canessa
Originals

Summary

The effect of an i.v. bolus of the H2-receptor antagonist ranitidine 50, 100, 200 and 300 mg on serum levels of prolactin, TSH, GH, LH, FSH and cortisol was studied in 12 normal males. Ranitidine 200 and 300 mg significantly stimulated prolactin release without affecting any of the other hormones. Ranitidine 300 mg caused a rise in prolactin comparable to that observed following cimetidine 200 mg. The results show that ranitidine releases prolactin in man, but only when a large intravenous injection is given.

Key words

ranitidine H2-antagonist cimetidine anterior pituitary hormone secretion PRL TSH GH LH FSH cortisol 

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References

  1. 1.
    Snyder SH, Taylor KM (1972) Histamine in the brain: a neurotransmitter? In: Snyder SH (ed), Perspectives in neuropharmacology: A tribute to Julius Axelrod. Oxford University Press, New York, pp 43–47Google Scholar
  2. 2.
    Taylor KM, Gfeller F, Snyder H (1972) Regional localization of histamine and histidine in the brain of the rhesus monkey. Brain Res 4: 171–179Google Scholar
  3. 3.
    Brownstein MJ, Saadevra JM, Palkovits M, Axelrod J (1974) Histamine content of hypothalamic nuclei of the rat. Brain Res 77: 151–156Google Scholar
  4. 4.
    Donoso AO, Banzan AM, Borzino MO (1976) Prolactin and luteinizing hormone release after intraventricular injection of histamine in rats. J Endocrinol 68: 171–172Google Scholar
  5. 5.
    Rivier C, Vale W (1977) Effects of gamma-aminobutyric acid and histamine on prolactin secretion in the rat. Endocrinology 101: 506–511Google Scholar
  6. 6.
    Carlson HE, Ippoliti AF (1977) Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man. J Clin Endocrinol Metab 45: 367–370Google Scholar
  7. 7.
    Delitala G, Stubbs WA, Wass JHA, Jones A, Williams S, Besser GM (1979) Effects of the H2 receptor antagonist cimetidine on pituitary hormones in man. Clin Endocrinol (Oxf) 11: 161–167Google Scholar
  8. 8.
    Brimblecombe RW, Duncan WAM, Durant GJ, Ganellin CR, Parson ME, Black JW (1975) The pharmacology of cimetidine, a new histamine H2-receptor antagonist. Br J Pharmacol 53: 435–451Google Scholar
  9. 9.
    Peden NR, Saunders JHB, Wormsley KG (1979) Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. Lancet 1: 690Google Scholar
  10. 10.
    Domschke W, Lux G, Domschke S (1979) Gastric inhibitory action of H2 antagonists ranitidine and cimetidine. Lancet 1: 320–322Google Scholar
  11. 11.
    Daubresse JC, Meunier JC, Ligny G (1979) Effects of acute and chronic cimetidine administration on the pituitary-testicular axis. Agressologie 2O: 771–774Google Scholar
  12. 12.
    Arakelian MC, Libertun C (1977) H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats. Endocrinology 100: 890–895Google Scholar
  13. 13.
    Donoso AO, Banzan AM (1980) H1- and H2-histamine receptor antagonists and induced release of prolactin in male rats. Neuroendocrinology 30: 11–14Google Scholar
  14. 14.
    Thorner MO, Besser GM (1978) Clinical significance of dopaminergic mechanisms in the hypothalamus and pituitary. In: O'Riordan JHL (ed.) Recent advances in endocrinology and metabolism. Churchill Livingstone, Edinburgh, pp 1–15Google Scholar
  15. 15.
    Delitala G, Stubbs WA, Yeo T, Jones A, Besser GM (1979) Failure of cimetidine to antagonise dopamine-induced suppression on prolactin in vitro. Br J Clin Pharmacol 7: 117–119Google Scholar
  16. 16.
    Yeo T, Delitala G, Besser GM, Edwards CRW (1980) The effects of ranitidine on pituitary hormone secretion in vitro. Br J Clin Pharmacol 10: 171–173Google Scholar
  17. 17.
    La Brooy SJ, Misiewicz JJ, Delitala G, Jones A, Edwards CRW, Besser GM, Stubbs WA, Alberti KGMM (1978) Studies on the effect of cimetidine on anterior pituitary hormones: are they clinically relevant? Proc Br Soc Gastroenterol, Edinburgh, September 20–23, Abstract n. S 3Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. Delitala
    • 1
    • 2
  • L. Devilla
    • 1
  • A. Pende
    • 1
  • A. Canessa
    • 1
  1. 1.Department of Internal MedicineI.S.M.I., Cattedra di Semeiotica Medica RGenoaItaly
  2. 2.Istituto di Patologia Speciale Medica 1aSassari, SardiniaItalia

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