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Acetylator phenotyping: A comparison of the isoniazid and dapsone tests

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Summary

A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on 5 samples (0–6 h), and by determination of the ratio of monoacetylated (MAD) to unchanged dapsone (DDS) in a single sample obtained 3 h after dapsone intake. In each of 44 subjects examined, there was unequivocal agreement about classification of the subject as a rapid (INH t1/2 <2 h; MAD/DDS >0.3) or slow (INH t1/2 >2 h; MAD/DDS <0.3) acetylator. It appears that the single-sample (3 h) dapsone test is as reliable as the more laborious and time-consuming INH test for acetylator phenotyping.

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Authors and Affiliations

  1. Department of Clinical Chemistry (Section of Toxicology) and Clinical Pharmacology, University of Lund, Sweden

    A. Hanson, A. Melander & E. Wåhlin-Boll

  2. Department of Clinical Chemistry (Section of Toxicology) and Clinical Pharmacology, Malmö General Hospital, Sweden

    A. Hanson, A. Melander & E. Wåhlin-Boll

  3. Department of Community Care Sciences, Dalby, Sweden

    A. Hanson, A. Melander & E. Wåhlin-Boll

Authors
  1. A. Hanson
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  2. A. Melander
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  3. E. Wåhlin-Boll
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Hanson, A., Melander, A. & Wåhlin-Boll, E. Acetylator phenotyping: A comparison of the isoniazid and dapsone tests. Eur J Clin Pharmacol 20, 233–234 (1981). https://doi.org/10.1007/BF00544604

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  • DOI: https://doi.org/10.1007/BF00544604

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