Virchows Archiv A

, Volume 349, Issue 3, pp 215–228 | Cite as

A stereomicroscopic study of the mastopathic human breast

II. Peripheral type of duct evolution and its relation to cystic disease
  • Yasukazu Tanaka
  • Kunio Oota


The stereomicroscopic study of cystic disease of the breast revealed the presence of abnormal ductules near the terminal sites of the original lactiferous ducts. This alteration was the key feature of cystic disease since the involution of abnormal ductules possibly may have induced the stricture of the original duct by increasing fibrosis around the site of duct evolution. The phenomenon could contribute to the creation of cystic dilatation of distal ducts and acini. Multiple large cysts characterizing the morphology of cystic disease may represent the end stage of distended ducts and acini. Prolonged and repeated unbalanced stimulation of hormones could produce progressive and regressive alternations in the same breast. This modifies the original alteration into more pleomorphic and complicated types.


Public Health Large Cyst Cystic Disease Cystic Dilatation Terminal Site 
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Stereomikroskopische Studie der durch Mastopathie veränderten menschlichen Mamma

II. Die peripherische Form der Milchgangsevolution und ihre Beziehung zur Cystenmamma


Die stereomikroskopische Untersuchung sog. Cystenmmamen zeigt, daß die Cysten durch Ektasie der sog. Kanälchen-Endäste entstehen. Dagegen werden die Stamm-Milchgänge einer Involution zugeführt. An der Cystenbildung beteiligen sich auch die Acini. Als morphogenetische Reize kommen hormonelle Dysregulatonen in Frage. Durch die unterschiedliche Ausbildung der Kanälchen proliferation einerseits, die Involution sowie Cystenbildung andererseits resultiert ein buntes, wenig einheitliches Bild.


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • Yasukazu Tanaka
    • 1
    • 2
    • 3
  • Kunio Oota
    • 1
    • 2
  1. 1.Department of Pathology, Faculty of MedicineTokyo Medical and Dental UniversityJapan
  2. 2.Department of Pathology, Faculty of MedicineUniversity of TokyoJapan
  3. 3.Veterans Administration HospitalSan FranciscoUSA

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