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European Journal of Clinical Pharmacology

, Volume 33, Issue 2, pp 185–189 | Cite as

Effect of age on the pharmacokinetics of vinpocetine (Cavinton) and apovincaminic acid

  • P. Miskolczi
  • L. Vereczkey
  • L. Szalay
  • C. Göndöcs
Originals

Summary

The pharmacokinetics of vinpocetine and its main metabolite, apovincaminic acid (AVA), were studied in the aged. Vinpocetine was eliminated with a mean half-life of 2.12±0.51 h. Total plasma clearance (CL) and distribution coefficient (Δ) of the parent drug were 2.2±0.9 l · kg−1 · h−1 and 6.7±3.7 l · kg−1, respectively. The CL and Δ of vinpocetine differed significantly from young subjects but the elimination half-life was not altered. Significant changes in the elimination half-life and plasma clearance of AVA were found, perhaps because of the physiological decrease in renal function.

Key words

vinpocetine apovincaminic acid healthy volunteers elderly subjects pharmacokinetics age effect 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • P. Miskolczi
    • 1
  • L. Vereczkey
    • 1
  • L. Szalay
    • 2
  • C. Göndöcs
    • 2
  1. 1.Department of Pharmacokinetics and Drug MetabolismChemical Works of Gedeon Richter Ltd.BudapestHungary
  2. 2.II Department of MedicineSemmelweis University Medical SchoolBudapestHungary

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