Summary
The study was undertaken to look for a correlation between the measured elimination rate constants (k) of aminoglycosides and creatinine during haemodialysis. The pharmacokinetics of aminoglycosides were studied during 44 courses of haemodialysis in 21 patients.
The measured k of gentamicin and tobramycin from the start until 30 min after the end of haemodialysis (mean 0.18 h−1; t1/2=3 h 51 min) was significantly correlated with the measured k of creatinine (mean 0.13 h−1; t1/2=5 h, 20 min), and also with the gentamicin and tobramycin k during haemodialysis (mean 0.20 h−1, t1/2=3 h, 28 min), as predicted by a computer program.
Thus, serum concentrations of aminoglycosides 30 min after haemodialysis can be estimated by simple regression equations. However, because the measured and predicted values may diverge considerably in the individual patient, monitoring of aminoglycoside concentrations in serum after haemodialysis remains necessary.
Similar content being viewed by others
References
Burd JF, Wong RC, Feeney JE, Carrico RJ, Boguslaski RC (1977) Homogeneous reactant-labeled fluorescent immunoassay for therapeutic drugs exemplified by gentamicin determination in human serum. Clin Chem 23: 1402–1408
Curtis JR, McDonald SJ, Weston JH (1967) Parenteral administration of gentamicin in renal failure: Patients undergoing intermittent haemodialysis. Br Med J 2: 537–539
Danish M, Schultz R, Jusko WJ (1974) Pharmacokinetics of gentamicin and kanamycin during hemodialysis. Antimicrob Agents Chemother 6: 841–847
Halpren BJ, Axline SG, Coplon NS, Brown DM (1976) Clearance of gentamycin during hemodialysis. Comparison of four artificial kidneys. J Infect Dis 133: 627–636
Lockwood WR, Bower JD (1973) Tobramycin and gentamicin concentrations in the serum of normal and anephric patients. Antimicrob Agents Chemother 3: 125–129
Mattie H, Goslings WRO, Noach EL (1973) Cloxacillin and nafcillin: Serum binding and its relationship to antimicrobial effect in mice. J Infect Dis 128: 170–177
Mawer GE, Knowles BR, Lucas SB, Stirland RW, Tooth JA (1972) Computer-assisted prescribing of kanamycin for patients with renal insufficiency. Lancet 1: 12–15
Mawer GE (1976) Computer assisted prescribing of drugs. Clin Pharmacokinet 1: 67–78
Regeur L, Colding H, Jensen H, Kampmann JP (1977) Pharmacokinetics of amikacin during hemodialysis and peritoneal dialysis. Antimicrob Agents Chemother 11: 214–218
Riff LJ, Jackson GG (1971) Pharmacology of gentamicin in man. J Infect Dis 124: S98-S105
Root RK, Hierholtzer WJ (1978) Infectious disease. In: Melmon KL, Morelli HW (eds) Clinical pharmacology, 2nd. Macmillan, New York, pp 754–758
Siersbaek-Nielsen K, Hansen JM, Kampmann J, Kristensen M (1971) Rapid evaluation of creatinine clearance. Lancet 1: 1133–1134
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dijkmans, B.A.C., Mattie, H. Predictability of serum concentrations of aminoglycosides after haemodialysis. Eur J Clin Pharmacol 33, 179–183 (1987). https://doi.org/10.1007/BF00544564
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00544564