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European Journal of Clinical Pharmacology

, Volume 28, Issue 4, pp 479–481 | Cite as

Plasma protein binding of ritodrine at parturition and in nonpregnant women

  • A. S. Gross
  • K. F. Brown
Short Communications

Summary

The binding of ritodrine HCl in whole plasma from healthy nonpregnant women, parturients and matched umbilical venous plasma and in solutions of HSA and α1-AGP has been studied by equilibrium dialysis. Binding to plasma from nonpregnant subjects and HSA was independent of ritodrine concentration over a wide range.

The free fraction in plasma was high and significantly different between groups of nonpregnant (α=0.64), parturient (α=0.68) and matched umbilical venous plasma (α=0.75). It would seem that variability in transplacental transfer of ritodrine, as a result of plasma binding fluctuations, will be minor.

Key words

plasma protein binding ritodrine hydrochloride albumin binding alpha1-acid glycoprotein parturition 

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References

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. S. Gross
    • 1
    • 2
  • K. F. Brown
    • 1
  1. 1.Department of PharmacyUniversity of SydneySydneyAustralia
  2. 2.Foetal Pharmacology LaboratoryAustralia

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