European Journal of Clinical Pharmacology

, Volume 28, Issue 4, pp 479–481 | Cite as

Plasma protein binding of ritodrine at parturition and in nonpregnant women

  • A. S. Gross
  • K. F. Brown
Short Communications


The binding of ritodrine HCl in whole plasma from healthy nonpregnant women, parturients and matched umbilical venous plasma and in solutions of HSA and α1-AGP has been studied by equilibrium dialysis. Binding to plasma from nonpregnant subjects and HSA was independent of ritodrine concentration over a wide range.

The free fraction in plasma was high and significantly different between groups of nonpregnant (α=0.64), parturient (α=0.68) and matched umbilical venous plasma (α=0.75). It would seem that variability in transplacental transfer of ritodrine, as a result of plasma binding fluctuations, will be minor.

Key words

plasma protein binding ritodrine hydrochloride albumin binding alpha1-acid glycoprotein parturition 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barden TP, Peter JB, Merkatz IR (1980) Ritodrine hydrochloride: A betamimetic agent for use in preterm labour. I. Pharmacology, clinical history, administration, side-effects and safety. Obstet Gynecol 56: 1–6Google Scholar
  2. 2.
    Gandar R, de Zoeten LW, van der Schoot JB (1980) Serum level of ritodrine in man. Eur J Clin Pharmacol 17: 117–122Google Scholar
  3. 3.
    van Lierde M, Thomas K (1982) Ritodrine concentrations in maternal and fetal serum and amniotic fluid. J Perinat Med 10: 119–124Google Scholar
  4. 4.
    Gallango M, Montiel N, Suinaga R (1981) Human albumin from cord blood: some distinctive characteristics. Biochem Med 26: 127–134Google Scholar
  5. 5.
    Wallace S (1976) Factors affecting drug-protein binding in the plasma of newborn infants. Br J Clin Pharmacol 3: 510–512Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. S. Gross
    • 1
    • 2
  • K. F. Brown
    • 1
  1. 1.Department of PharmacyUniversity of SydneySydneyAustralia
  2. 2.Foetal Pharmacology LaboratoryAustralia

Personalised recommendations