Advertisement

Virchows Archiv A

, Volume 354, Issue 1, pp 17–23 | Cite as

Mast cells in the islets of langerhans in insular amyloidosis

  • Per Westermark
Article

Summary

The number of mast cells in the pancreatic islets in persons 60 years or more without diabetes and with maturity-onset diabetes was determined in an autopsy study. Few mast cells were seen in sections of many islets without amyloid. In the presence of insular amyloidosis the number of intrainsular mast cells increased and this increase was positively correlated with to the amount of amyloid in the islets, both in diabetics and non-diabetics. It is conceivable that the mast cells are of some importance in the formation of amyloid in the pancreatic islets, but other explanations for the numerical increase in mast cells are possible.

Keywords

Public Health Diabetes Mellitus Mast Cell Amyloidosis Mast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

In einer Autopsieuntersuchung wurde die Anzahl von Mastzellen in den Pankreasinseln von 60jährigen und älteren Personen ohne Diabetes mellitus und mit Altersdiabetes bestimmt. Einige wenige Mastzellen wurden in Regionen vieler Inseln ohne Amyloid beobachtet. Bei Vorliegen von Amyloidosis war die Anzahl intrainsulärer Mastzellen erhöht, wobei diese Erhöhung eine positive Korrelation zur Menge Amyloid in den Inseln aufwies, sowohl in Diabetikern als auch Nicht-Diabetikern. Es ist denkbar, daß die Mastzellen eine Rolle im Zusammenhang mit der Amyloidbildung in den Pankreasinseln spielen, jedoch sind andere Ursachen für die zahlenmäßige Erhöhung der Mastzellen nicht auszuschließen.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arvy, L., Quivy, D.: Données sur la répartition des labrocytes chez le chien. C. R. Ass. Anat. 42, 234–241 (1955).Google Scholar
  2. Asboe-Hansen, G.: Mast cells in health and disease. Bull. N. Y. Acad. Med. 44, 1048–1056 (1968).Google Scholar
  3. Bell, E. T.: Hyalinization of the islets of Langerhans in Diabetes mellitus. Diabetes 1, 341–344 (1952).Google Scholar
  4. —— Hyalinization of the islets of Langerhans in non-diabetic individuals. Amer. J. Path. 35, 801–805 (1959).Google Scholar
  5. Bower, D., Chadwin, C. G.: Simultaneous demonstration of mast cells and plasma cells. J. clin. Path. 19, 298–299 (1966).Google Scholar
  6. Brini, A., Porte, A.: Amylose isolée de la conjonctive. Étude au microscope électronique. Arch. Ophtal. (Paris) 30, 231–244 (1970).Google Scholar
  7. Christensen, H. E.: Improved histochemical staining techniques for mucopolysaccharides applied to experimental and human amyloids. In: Amyloidosis (Mandema, E., Ruinen, L., Scholten, J. H., Cohen, A. S., eds.), p. 235. Amsterdam: Excerpta Medica Foundation 1968.Google Scholar
  8. Ehrlich, J. C., Ratner, I. M.: Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and nondiabetic individuals. Amer. J. Path. 38, 49–59 (1961).Google Scholar
  9. Enerbäck, L.: Mast cells in rat gastrointestinal mucosa. I. Effects of fixation. Acta path. microbiol. scand. 66, 289–302 (1966a).Google Scholar
  10. —— Mast cells in rat gastrointestinal mucosa. 2. Dye-binding and metachromatic properties. Acta path. microbiol. scand. 66, 303–312 (1966b).Google Scholar
  11. Kelsall, M. A., Crabb, E. D.: Lymphocytes and mast cells. Baltimore: Williams & Wilkins Company 1959.Google Scholar
  12. Lacy, P. E.: Pancreatic beta cell. In: Aetiology of diabetes mellitus and its complications. Ciba Foundation Colloquia on Endocrinology, vol. 15, p. 75. Boston: Little, Brown & Company 1964.Google Scholar
  13. Ogilvie, R. F.: The endocrine pancreas in human diabetes. In: The structure and metabolism of the pancreatic islets (Brolin, S. E., Hellman, B., Knutson, H., eds.), p. 499. Oxford: Pergamon Press 1964.Google Scholar
  14. Opie, E. L.: On relation of chronic interstitial pancreatitis to the islands of Langerhans and to diabetes mellitus. J. exp. Med. 5, 397–428 (1900).Google Scholar
  15. Pearse, A. G. E.: Histochemistry. Theoretical and applied, 2nd ed. London: J. & A. Churchill Ltd 1960.Google Scholar
  16. Puchtler, H., Sweat, F., Levine, M.: On the binding of Congo red by amyloid. J. Histochem. Cytochem. 10, 355–364 (1962).Google Scholar
  17. Ranl∅v, P., Wanstrup, J.: Electron-microscopic demonstration of intracellular amyloid in experimental mouse amyloidosis. In: Amyloidosis (Mandema, E., Ruinen, L., Scholten, J. H., Cohen, A. S., eds.), p. 74. Amsterdam: Excerpta Medica Foundation 1968.Google Scholar
  18. Schwartz, P.: Über Amyloidose des Gehirns, der Langerhansschen Inseln und des Herzens alter Personen. Zbl. allg. Path. path. Anat. 108, 169–187 (1965).Google Scholar
  19. Selye, H.: The mast cells. Washington: Butterworths (1965).Google Scholar
  20. Staemmler, M.: Untersuchung über Vorkommen und Bedeutung der histiogenen Mastzellen im menschlichen Körper unter normalen und pathologischen Verhältnissen. Frankfurt. Z. Path. 25, 391–435 (1921).Google Scholar
  21. Steiner, H.: Endokrin aktive Tumoren mit Amyloidstroma. Eine morphologische Untersuchung von Insulinomen und einem Calcitonin produzierenden Tumor. Virchows Arch. Abt. A 348, 170–180 (1969).Google Scholar
  22. Teilum, G.: Pathogenesis of amyloidosis. The two-phase cellular theory of local secretion. Acta path. microbiol. scand. 61, 21–45 (1964).Google Scholar
  23. Warren, S., LeCompte, P. M., Legg, M. A.: the pathology of diabetes mellitus. Philadelphia: Lea & Febiger 1966.Google Scholar
  24. Zimmermann, A.: Über das Vorkommen der Mastzellen beim Meerschweinchen. Arch. mikr Anat. 72, 662–670 (1908).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Per Westermark
    • 1
  1. 1.Department of PathologyUniversity of UppsalaUppsalaSweden

Personalised recommendations