European Journal of Clinical Pharmacology

, Volume 27, Issue 2, pp 227–232 | Cite as

Effect of cimetidine on the metabolism of cholephilic dyes in Gilbert's syndrome

  • K. Kutz
  • M. Deres


The metabolism of indocyanine green, bromsulphophthalein and bilirubin was studied before and after a treatment for 2 weeks with cimetidine 1.0 g/day in 12 subjects with Gilbert's syndrome. There was no effect on the plasma clearance of indocyanine green and bromsulphophthalein, on the maximal biliary excretion capacity of bromsulphophthalein, on serum bilirubin concentrations or on the biliary metabolites of bromsulphophthalein and bilirubin. It is concluded that in Gilbert's syndrome two weeks of treatment with cimetidine had no effect on liver blood flow or on conjugation mechanisms which were independent of cytochrome P450.

Key words

cimetidine indocyanine green bromsulphophthalein bilirubin Gilbert's syndrome drug metabolism drug conjugation 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • K. Kutz
    • 1
    • 2
  • M. Deres
    • 1
  1. 1.Medizinische PoliklinikUniversity of BonnBonnFederal Republik of Germany
  2. 2.Department of Experimental TherapeuticsSandoz Ltd.BasleSwitzerland

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