European Journal of Clinical Pharmacology

, Volume 27, Issue 2, pp 173–179 | Cite as

Influence of triazolam on thermal heat balance in poor sleepers

  • J. -P. Libert
  • L. D. Weber
  • C. Amoros
  • A. Muzet
  • J. Ehrhart
  • M. Follenius


The influence of a benzodiazepine (triazolam) on the body temperature of poor sleepers during nights disturbed by airplane noises has been examined. Subjects were divided into 3 groups each of 8 men. Following a double-blind design, Group A (controls) received a placebo for 6 consecutive nights, Group B received 0.25 mg triazolam, and Group C received 0.5 mg triazolam on nights N3, N4 and N5. On all other nights Group B and C subjects received placebo. For all 3 groups, nights N3 and N5 were disturbed by 32, semi-randomly distributed airplane noises. Air and wall temperatures (To=20°C), and air humidity (Tdp=10°C), were kept constant. Rectal temperature and 4 local skin temperatures were recorded from each subject. Urine samples were collected each morning for measurement of cortisol and catecholamine levels. Noise was found to cause an increase in body heat storage, but only in Group A. Both drug groups showed impairment of body heat balance. The hypothermic action of triazolam could be explained both by a central action of the drug on the thermoregulatory controller and by a peripheral action on blood vessels.

Key words

benzodiazepine thermoregulation sleep rectal temperature mean skin temperature noise triazolam cortisol excretion urinary catecholamines 


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  1. 1.
    Braestrup C, Albrechtsen R, Squires RF (1977) High densities of benzodiazepine receptor in human cortical areas. Nature 269: 702–704Google Scholar
  2. 2.
    Candas V, Libert JP, Vogt JJ, Ehrhart J, Muzet A (1979) Body temperature during sleep under different thermal conditions. In: Fanger PO, Valbjorn O (eds) Indoor climate: effects on human comfort, performance and health. JJ Trykteknik, Copenhagen, pp 763–776Google Scholar
  3. 3.
    Church MW, Johnson LC, Seales DM, Rossiter VS (1978) Bedtime and morning oral temperatures, evoked cardiovascular responses, and spontaneous skin potential responses in good and poor sleepers and the effects of flurazepam. Sleep Res 7: 65Google Scholar
  4. 4.
    Côté P, Noble J, Bourassa MG (1976) Systemic vasodilatation following diazepam after combined sympathetic and parasympathetic blockade in patients with coronary heart disease. Cathet Cardiovasc Diagn 2: 369–380Google Scholar
  5. 5.
    Follenius M, Brandenberger G, Lecornu C, Simeoni M, Reinhardt B (1980) Plasma catecholamines and pituitary adrenal hormones in response to noise exposure. Eur J Appl Physiol 43: 253–261Google Scholar
  6. 6.
    Henkins RI, Knigge KM (1963) Effect of sound on the hypothalamic pituitary adrenal axis. Am J Physiol 204: 710–714Google Scholar
  7. 7.
    Irvine RE (1966) Hypothermia due to diazepam. Br Med J 2: 1007Google Scholar
  8. 8.
    Knipschild P (1977) Medical effects of aircraft noise. Int Arch Occup Environ Health 40: 185–204Google Scholar
  9. 9.
    Muzet A, Johnson LC, Spinweber CL (1982) Benzodiazepine hypnotics increase heart rate during sleep. Sleep 5: 256–261Google Scholar
  10. 10.
    Ogle CW, Lockett MF (1968) The urinary changes induced in rats by high pitched sounds (20 kcyc./sec). J Endocrinol 42: 253–260Google Scholar
  11. 11.
    Passon PG, Peuler JD (1973) A simplified radiometric assay for plasma norepinephrine and epinephrine. Anal Biochem 51: 618–631Google Scholar
  12. 12.
    Peuler JD, Johnson GA (1977) Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. Life Sci 21: 625–636Google Scholar
  13. 13.
    Ramanathan NL (1964) A new weighting system for mean surface temperature of the human body. J Appl Physiol 19: 531–533Google Scholar
  14. 14.
    Slob A, Wink A, Radder JJ (1973) The effect of acute noise exposure on the secretion of corticosteroids, adrenalin and noradrenalin in man. Int Arch Arbeitsmed 31: 225–235Google Scholar
  15. 15.
    Stolwijk JAJ, Hardy JD (1966) Partitional calorimetric studies of responses of man to thermal transients. J Appl Physiol 21: 967–977Google Scholar
  16. 16.
    Vecsei P, Penke B, Katzy R, Baek L (1972) Radioimmunological determination of plasma cortisol. Experientia 8: 1104–1106Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. -P. Libert
    • 1
  • L. D. Weber
    • 1
  • C. Amoros
    • 1
  • A. Muzet
    • 1
  • J. Ehrhart
    • 1
  • M. Follenius
    • 1
  1. 1.Centre d'Etudes Bioclimatiques du C.N.R.S. Groupe Physiologie EnvironnementaleStrasbourgFrance

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